Trial reportBipolar disorders2012
A randomized pilot study of psychotherapy and quetiapine for the acute treatment of bipolar II depression.
Trial report in Bipolar disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00411463 (Psychotherapy for Bipolar II Depression, Pilot Study, Phase II), which is not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Psychotherapy for Bipolar II Depression, Pilot Study, Phase II
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Toward a Digital Future in Bipolar Disorder Assessment: A Systematic Review of Disruptions in the Rest-Activity Cycle as Measured by Actigraphy.Frontiers in psychiatry · 2022Pooled it
- Quetiapine for acute bipolar depression: a systematic review and meta-analysis.Drug design, development and therapy · 2014Pooled it
- Psychotherapy Alone and Combined With Medication as Treatments for Bipolar II Depression: A Randomized Controlled Trial.The Journal of clinical psychiatryTrial
- Co-designing and piloting adolescent-adapted social rhythm therapy for young people with unipolar and bipolar depression: a mixed-methods feasibility case series.Frontiers in child and adolescent psychiatry · 2026Article
- Everyday life experiences for evaluating post-traumatic stress disorder symptoms.European journal of psychotraumatology · 2023Article
- Evidence-Based Psychotherapies for Bipolar Disorder.Focus (American Psychiatric Publishing) · 2019Review
- Treating Circadian Rhythm Disruption in Bipolar Disorder.Current psychiatry reports · 2019Review
- Transdiagnostic treatment of bipolar disorder and comorbid anxiety using the Unified Protocol for Emotional Disorders: A pilot feasibility and acceptability trial.Journal of affective disorders · 2017Article
- Circadian Rhythm Dysregulation in Bipolar Spectrum Disorders.Current psychiatry reports · 2017Review
- The International College of Neuro-Psychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 2: Review, Grading of the Evidence, and a Precise Algorithm.The international journal of neuropsychopharmacology · 2017Review
- Prediction of near-term increases in suicidal ideation in recently depressed patients with bipolar II disorder using intensive longitudinal data.Journal of affective disorders · 2017Article
- Social Rhythm Therapies for Mood Disorders: an Update.Current psychiatry reports · 2016Review
- Psychosocial treatment and interventions for bipolar disorder: a systematic review.Annals of general psychiatry · 2015Article
- Psychotherapy for Bipolar Disorder in Adults: A Review of the Evidence.Focus (American Psychiatric Publishing) · 2014Article
- Circadian rhythms and psychiatric illness.Current opinion in psychiatry · 2013Review
- Differences between unipolar depression and bipolar II depression in women.Journal of affective disorders · 2013Article
- Treatment of bipolar disorder.Lancet (London, England) · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesThe differential roles of psychotherapy and pharmacotherapy in the management of bipolar (BP) II depression are unknown. As a first step toward exploring this issue, we conducted a pilot study to evaluate the feasibility and acceptability of comparing a BP-specific psychotherapy [Interpersonal and Social Rhythm Therapy (IPSRT)] to quetiapine as treatments for BP-II depression.
methodsUnmedicated individuals (n = 25) meeting DSM-IV criteria for BP-II disorder, currently depressed, were randomly assigned to weekly sessions of IPSRT (n = 14) or quetiapine (n = 11), flexibly dosed from 25-300 mg. Participants were assessed with weekly measures of mood and followed for 12 weeks. Treatment preference was queried prior to randomization.
resultsUsing mixed effects models, both groups showed significant declines in the 25-item Hamilton Rating Scale for Depression [F(1,21) = 44, p < 0.0001] and Young Mania Rating Scale [F(1,21) = 20, p = 0.0002] scores over time but no group-by-time interactions. Dropout rates were 21% (n = 3) and 27% (n = 3) in the IPSRT and quetiapine groups, respectively. Overall response rates (defined as ≥ 50% reduction in depression scores without an increase in mania scores) were 29% (n = 4) in the IPSRT group and 27% (n = 3) in the quetiapine group. Measures of treatment satisfaction were high in both groups. Treatment preference was not associated with outcomes.
conclusionsOutcomes in participants with BP-II depression assigned to IPSRT monotherapy or quetiapine did not differ over 12 weeks in this small study. Follow-up trials should examine characteristics that predict differential response to psychotherapy and pharmacotherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.