ArticleJournal of neuroinflammation2012
A lack of association between elevated serum levels of S100B protein and autoimmunity in autistic children.
Article in Journal of neuroinflammation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Peripheral Blood S100B Levels in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis.Journal of autism and developmental disorders · 2021Pooled it
- Pooled it
- S100B Serum Levels Predict Treatment Response in Patients with Melancholic Depression.The international journal of neuropsychopharmacology · 2015Trial
- Nitric Oxide-S-Nitrosylation and Its Role in Neuroinflammation Associated with Neuropsychiatric Conditions.International journal of molecular sciences · 2026Review
- Immune-related mechanisms of fecal microbiota transplantation in the intestinal microenvironment as a potential intervention for autism spectrum disorder patients.Frontiers in pharmacology · 2026Review
- Diverse role of S100 calcium-binding protein B in alzheimer's disease: pathological mechanisms and therapeutic implications.Inflammopharmacology · 2025Review
- Gut Microbiota and Autism Spectrum Disorder: A Neuroinflammatory Mediated Mechanism of Pathogenesis?Inflammation · 2025Review
- Peripheral S100B Protein Levels in Five Major Psychiatric Disorders: A Systematic Review.Brain sciences · 2023Review
- Neurovascular crosstalk and cerebrovascular alterations: an underestimated therapeutic target in autism spectrum disorders.Frontiers in cellular neuroscience · 2023Review
- S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis.Translational psychiatry · 2021Article
- The Novel Potential Therapeutic Utility of Montelukast in Alleviating Autistic Behavior Induced by Early Postnatal Administration of Thimerosal in Mice.Cellular and molecular neurobiology · 2021Article
- High Serum Levels of Serum 100 Beta Protein, Neuron-specific Enolase, Tau, Active Caspase-3, M30 and M65 in Children with Autism Spectrum Disorders.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2020Article
- Chronic maternal interleukin-17 and autism-related cortical gene expression, neurobiology, and behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Probiotics and oxytocin nasal spray as neuro-social-behavioral interventions for patients with autism spectrum disorders: a pilot randomized controlled trial protocol.Pilot and feasibility studies · 2020Article
- Do Alarmins Have a Potential Role in Autism Spectrum Disorders Pathogenesis and Progression?Biomolecules · 2018Review
- Peripheral Inflammatory Markers Contributing to Comorbidities in Autism.Behavioral sciences (Basel, Switzerland) · 2016Article
- The positive association between elevated blood lead levels and brain-specific autoantibodies in autistic children from low lead-polluted areas.Metabolic brain disease · 2016Article
- Increased production of IL-17 in children with autism spectrum disorders and co-morbid asthma.Journal of neuroimmunology · 2015Article
- Serum antinucleosome-specific antibody as a marker of autoimmunity in children with autism.Journal of neuroinflammation · 2014Article
- Redox Regulation and the Autistic Spectrum: Role of Tryptophan Catabolites, Immuno-inflammation, Autoimmunity and the Amygdala.Current neuropharmacology · 2014Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundS100B is a calcium-binding protein that is produced primarily by astrocytes. Increased serum S100B protein levels reflect neurological damage. Autoimmunity may have a role in the pathogenesis of autism in some patients. Autoantibodies may cross the blood-brain barrier and combine with brain tissue antigens, forming immune complexes and resulting in neurological damage. We are the first to investigate the relationship between serum levels of S100B protein, a marker of neuronal damage, and antiribosomal P protein antibodies in autistic children.
methodsSerum S100B protein and antiribosomal P antibodies were measured in 64 autistic children in comparison to 46 matched healthy children.
resultsAutistic children had significantly higher serum S100B protein levels than healthy controls (P < 0.001). Children with severe autism had significantly higher serum S100B protein than patients with mild to moderate autism (P = 0.01). Increased serum levels of antiribosomal P antibodies were found in 40.6% of autistic children. There were no significant correlations between serum levels of S100B protein and antiribosomal P antibodies (P = 0.29).
conclusionsS100B protein levels were elevated in autistic children and significantly correlated to autistic severity. This may indicate the presence of an underlying neuropathological condition in autistic patients. Antiribosomal P antibodies may not be a possible contributing factor to the elevated serum levels of S100B protein in some autistic children. However, further research is warranted to investigate the possible link between serum S100B protein levels and other autoantibodies, which are possible indicators of autoimmunity to central nervous system in autism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.