ArticleJournal of neuroscience research2012
Distinct roles of dopamine D3 receptors in modulating methamphetamine-induced behavioral sensitization and ultrastructural plasticity in the shell of the nucleus accumbens.
Article in Journal of neuroscience research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- A combined study of pharmacodynamics and pharmacokinetics of methamphetamine and its metabolite in male mice.European journal of medical research · 2025Article
- Dopamine D3 receptor signaling alleviates mouse rheumatoid arthritis by promoting Toll-like receptor 4 degradation in mast cells.Cell death & disease · 2022Article
- Knockout of Dopamine D3 Receptor Gene Blocked Methamphetamine-Induced Distinct Changes of Dopaminergic and Glutamatergic Synapse in the Nucleus Accumbens Shell of Mice.Frontiers in cellular neuroscience · 2022Article
- Amphetamine sensitization alters hippocampal neuronal morphology and memory and learning behaviors.Molecular psychiatry · 2021Article
- Identification of the Risk Genes Associated With Vulnerability to Addiction: Major Findings From Transgenic Animals.Frontiers in neuroscience · 2021Review
- Potential Ago2/miR-3068-5p Cascades in the Nucleus Accumbens Contribute to Methamphetamine-Induced Locomotor Sensitization of Mice.Frontiers in pharmacology · 2021Article
- Involvement of dopamine D3 receptor and dopamine transporter in methamphetamine-induced behavioral sensitization in tree shrews.Brain and behavior · 2020Article
- Ruboxistaurin Reduces Cocaine-Stimulated Increases in Extracellular Dopamine by Modifying Dopamine-Autoreceptor Activity.ACS chemical neuroscience · 2019Article
- The Effects of Non-selective Dopamine Receptor Activation by Apomorphine in the Mouse Hippocampus.Molecular neurobiology · 2018Article
- Article
- mRNA changes in nucleus accumbens related to methamphetamine addiction in mice.Scientific reports · 2016Article
- Aggregated single-walled carbon nanotubes attenuate the behavioural and neurochemical effects of methamphetamine in mice.Nature nanotechnology · 2016Article
- A selective D3 receptor antagonist YQA14 attenuates methamphetamine-induced behavioral sensitization and conditioned place preference in mice.Acta pharmacologica Sinica · 2016Article
- Differential modulation of methamphetamine-mediated behavioral sensitization by overexpression of Mu opioid receptors in nucleus accumbens and ventral tegmental area.Psychopharmacology · 2016Article
- BDNF-TrkB signaling in the nucleus accumbens shell of mice has key role in methamphetamine withdrawal symptoms.Translational psychiatry · 2015Article
- Methamphetamine induces alterations in the long non-coding RNAs expression profile in the nucleus accumbens of the mouse.BMC neuroscience · 2015Article
- Proteomics Analysis of Dorsal Striatum Reveals Changes in Synaptosomal Proteins following Methamphetamine Self-Administration in Rats.PloS one · 2015Article
- Recent advances in methamphetamine neurotoxicity mechanisms and its molecular pathophysiology.Behavioural neurology · 2015Review
- Genetic factors involved in risk for methamphetamine intake and sensitization.Mammalian genome : official journal of the International Mammalian Genome Society · 2013Article
- Disease-specific heteromerization of G-protein-coupled receptors that target drugs of abuse.Progress in molecular biology and translational science · 2013Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Persistent changes in behavior and psychological function that occur as a consequence of exposure to drugs of abuse are thought to be mediated by the structural plasticity of specific neural circuits such as the brain's dopamine (DA) system. Changes in dendritic morphology in the nucleus accumbens (NAc) accompany drug-induced enduring behavioral and molecular changes, yet ultrastructural changes in synapses following repeated exposure to drugs have not been well studied. The current study examines the role of DA D3 receptors in modulating locomotor activity induced by both acute and repeated methamphetamine (METH) administration and accompanying ultrastructural plasticity in the shell of NAc in mice. We found that D3 receptor mutant (D3−/−) mice exhibited attenuated acute locomotor responses as well as the development of behavioral sensitization to METH compared with wild-type mice. In the absence of obvious neurotoxic effects, METH induced similar increases in synaptic density in the shell of NAc in both wild-type and D3−/− mice. These results suggest that D3 receptors modulate locomotor responses to both acute and repeated METH treatment. In contrast, the D3 receptor is not obviously involved in modulating baseline or METH-induced ultrastructural changes in the NAc shell.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.