ArticleInterface focus2011
Modelling of pH dynamics in brain cells after stroke.
Article in Interface focus, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Article
- ¹H NMR Chemical Shifts and J-Coupling Constants Dependence on Temperature and pH: Implications for the Quantification of Relevant Metabolites.NMR in biomedicine · 2026Article
- Structural Descriptors and Antioxidant Activity Markers of 4-[4-(2-Aminoethoxy)benzyl]aniline.Antioxidants (Basel, Switzerland) · 2026Article
- Protamine-1 encoded recombinant adeno-associated virus for enhanced brain magnetic resonance imaging.Magnetic resonance letters · 2026Article
- Multimodal imaging evaluation of early neurological deterioration following acute ischemic stroke.Quantitative imaging in medicine and surgery · 2024Article
- Systems-level computational modeling in ischemic stroke: from cells to patients.Frontiers in physiology · 2024Review
- Early Metabolic Alteration Predicts Outcome With Middle Cerebral Artery Occlusion Treated by Mechanical Thrombectomy.Stroke (Hoboken, N.J.) · 2023Article
- The Oxygen and Glucose Deprivation of Immature Cells of the Nervous System Exerts Distinct Effects on Mitochondria, Mitophagy, and Autophagy, Depending on the Cells' Differentiation Stage.Brain sciences · 2023Article
- Stimuli-Responsive Nanotherapeutics for Treatment and Diagnosis of Stroke.Pharmaceutics · 2023Review
- Potential enhancement of post-stroke angiogenic response by targeting the oligomeric aggregation of p53 protein.Frontiers in cellular neuroscience · 2023Review
- Amide proton transfer-weighted magnetic resonance imaging for the diagnosis of symptomatic chronic intracranial artery stenosis: a feasibility study.Quantitative imaging in medicine and surgery · 2022Article
- A computational model of cardiomyocyte metabolism predicts unique reperfusion protocols capable of reducing cell damage during ischemia/reperfusion.The Journal of biological chemistry · 2022Article
- A MinireviewFrontiers in bioengineering and biotechnology · 2022Review
- Magnetic Resonance pH Imaging in Stroke - Combining the Old With the New.Frontiers in physiology · 2021Article
- Brain Energy Metabolism in Two States of Mind Measured by Phosphorous Magnetic Resonance Spectroscopy.Frontiers in human neuroscience · 2021Article
- Population pharmacokinetic approach for evaluation of treosulfan and its active monoepoxide disposition in plasma and brain on the basis of a rat model.Pharmacological reports : PR · 2020Article
- Correlations of amide proton transfer-weighted MRI of cerebral infarction with clinico-radiological findings.PloS one · 2020Article
- Amide proton transfer-weighted MRI can detect tissue acidosis and monitor recovery in a transient middle cerebral artery occlusion model compared with a permanent occlusion model in rats.European radiology · 2019Article
- Evaluation of the sensitivity of RMagnetic resonance imaging · 2019Article
- Glioma growth modeling based on the effect of vital nutrients and metabolic products.Medical & biological engineering & computing · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The identification of salvageable brain tissue is a major challenge at stroke presentation. Standard techniques used in this context, such as the perfusion-diffusion mismatch, remain controversial. There is thus a need for new methods to help guide treatment. The potential role of pH imaging in this context is currently being investigated. Intracellular pH varies as a function of local perfusion, intracellular energy stores and time. Low pH triggers the production of free radicals and affects the calcium balance of the cells, which may lead to apoptosis and cell death. Thus, the characterization of pH dynamics may have predictive value for cell death after stroke, particularly when combined with novel imaging techniques. Therefore, we have extended an existing model of brain cellular metabolism to simulate the pH response of cells to ischaemia. Simulation results for conditions of reduced cerebral blood flow show good agreement for the evolution of intracellular pH with previously reported measurements and encourage the development of quantitative pH imaging to validate the predictive value of pH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.