ArticleInterface focus2011
Differential and integral views of genetics in computational systems biology.
Article in Interface focus, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 53 citations in OpenAlex.
- Genetic modulation of yield and phenotypic plasticity of yield in winter wheat.Journal of experimental botany · 2026Article
- The causal arrows from genotype, environment, and management to plant phenotype are double headed.Journal of experimental botany · 2025Review
- Evolutionary and ecological perspectives on the wheat phenotype.Proceedings. Biological sciences · 2021Article
- Role of Phospholipases AFrontiers in pharmacology · 2021Article
- Causality in Biological Transmission: Forces and Energies.Microbiology spectrum · 2018Review
- Was the Watchmaker Blind? Or Was She One-Eyed?Biology · 2017Review
- Evolution viewed from physics, physiology and medicine.Interface focus · 2017Review
- Systems biology, emergence and antireductionism.Saudi journal of biological sciences · 2016Article
- Bridging Systems Medicine and Patient Needs.CPT: pharmacometrics & systems pharmacology · 2015Review
- Chasing Mendel: five questions for personalized medicine.The Journal of physiology · 2014Review
- Toward exercise as personalized medicine.Sports medicine (Auckland, N.Z.) · 2013Review
- A theory of biological relativity: no privileged level of causation.Interface focus · 2012Article
- Systems biology and cancer.Progress in biophysics and molecular biology · 2011Article
- Giant sucking sound: can physiology fill the intellectual void left by the reductionists?Journal of applied physiology (Bethesda, Md. : 1985) · 2011Review
- Workflow for generating competing hypothesis from models with parameter uncertainty.Interface focus · 2011Article
- Neo-Darwinism, the modern synthesis and selfish genes: are they of use in physiology?The Journal of physiology · 2011Review
- The Biological Implausibility of the Nature-Nurture Dichotomy & What It Means for the Study of Infancy.Infancy : the official journal of the International Society on Infant Studies · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article uses an integrative systems biological view of the relationship between genotypes and phenotypes to clarify some conceptual problems in biological debates about causality. The differential (gene-centric) view is incomplete in a sense analogous to using differentiation without integration in mathematics. Differences in genotype are frequently not reflected in significant differences in phenotype as they are buffered by networks of molecular interactions capable of substituting an alternative pathway to achieve a given phenotype characteristic when one pathway is removed. Those networks integrate the influences of many genes on each phenotype so that the effect of a modification in DNA depends on the context in which it occurs. Mathematical modelling of these interactions can help to understand the mechanisms of buffering and the contextual-dependence of phenotypic outcome, and so to represent correctly and quantitatively the relations between genomes and phenotypes. By incorporating all the causal factors in generating a phenotype, this approach also highlights the role of non-DNA forms of inheritance, and of the interactions at multiple levels.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.