ArticleInternational journal of nanomedicine2012
Novel magnetic fibrin hydrogel scaffolds containing thrombin and growth factors conjugated iron oxide nanoparticles for tissue engineering.
Article in International journal of nanomedicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 93 citations in OpenAlex.
- Magnetic Ionogel and Its Applications.Gels (Basel, Switzerland) · 2025Review
- Magnetic fibrin nanofiber hydrogel delivering iron oxide magnetic nanoparticles promotes peripheral nerve regeneration.Regenerative biomaterials · 2024Article
- Macro, Micro, and Nano-Inspired Bioactive Polymeric Biomaterials in Therapeutic, and Regenerative Orofacial Applications.Drug design, development and therapy · 2023Review
- Functionalized hydrogels in neural injury repairing.Frontiers in neuroscience · 2023Review
- Investigation of Signals and Transcription Factors for The Generation of Female Germ-Like Cells.Cell journal · 2022Article
- Enhanced postoperative cancer therapy by iron-based hydrogels.Biomaterials research · 2022Review
- Review
- Structure and refractive index of fibrin protofibril aggregates according to laser phase microscopy accompanied by DLS and AFM.Biomedical optics express · 2021Article
- Role of particle clusters on the rheology of magneto-polymer fluids and gels.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2020Article
- Magnetic particle templating of hydrogels: engineering naturally derived hydrogel scaffolds with 3D aligned microarchitecture for nerve repair.Journal of neural engineering · 2020Article
- Protein and Polysaccharide-Based Magnetic Composite Materials for Medical Applications.International journal of molecular sciences · 2019Review
- Shear Elasticity of Magnetic Gels with Internal Structures.Sensors (Basel, Switzerland) · 2018Article
- Fabrication and Characterization of Magnesium Ferrite-Based PCL/Aloe Vera Nanofibers.Materials (Basel, Switzerland) · 2017Article
- Differentiation of Human Endometrial Stem Cells into Schwann Cells in Fibrin Hydrogel as 3D Culture.Molecular neurobiology · 2016Article
- Composites of Polymer Hydrogels and Nanoparticulate Systems for Biomedical and Pharmaceutical Applications.Nanomaterials (Basel, Switzerland) · 2015Review
- Bioactive magnetic near Infra-Red fluorescent core-shell iron oxide/human serum albumin nanoparticles for controlled release of growth factors for augmentation of human mesenchymal stem cell growth and differentiation.Journal of nanobiotechnology · 2015Article
- Application of iron oxide anoparticles in neuronal tissue engineering.Neural regeneration research · 2015Article
- Article
- Temporal and spatial patterning of transgene expression by near-infrared irradiation.Biomaterials · 2014Article
- Cardiac differentiation of cardiosphere-derived cells in scaffolds mimicking morphology of the cardiac extracellular matrix.Acta biomaterialia · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Novel tissue-engineered magnetic fibrin hydrogel scaffolds were prepared by the interaction of thrombin-conjugated iron oxide magnetic nanoparticles with fibrinogen. In addition, stabilization of basal fibroblast growth factor (bFGF) was achieved by the covalent and physical conjugation of the growth factor to the magnetic nanoparticles. Adult nasal olfactory mucosa (NOM) cells were seeded in the transparent fibrin scaffolds in the absence or presence of the free or conjugated bFGF-iron oxide nanoparticles. The conjugated bFGF enhanced significantly the growth and differentiation of the NOM cells in the fibrin scaffolds, compared to the same or even five times higher concentration of the free bFGF. In the presence of the bFGF-conjugated magnetic nanoparticles, the cultured NOM cells proliferated and formed a three-dimensional interconnected network composed mainly of tapered bipolar cells. The magnetic properties of these matrices are due to the integration of the thrombin- and bFGF-conjugated magnetic nanoparticles within the scaffolds. The magnetic properties of these scaffolds may be used in future work for various applications, such as magnetic resonance visualization of the scaffolds after implantation and reloading the scaffolds via magnetic forces with bioactive agents, eg, growth factors bound to the iron oxide magnetic nanoparticles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.