ArticleClinical and vaccine immunology : CVI2012
Specificity of the tuberculin skin test is modified by use of a protein cocktail containing ESAT-6 and CFP-10 in cattle naturally infected with Mycobacterium bovis.
Article in Clinical and vaccine immunology : CVI, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Comparative performance of tuberculin and defined-antigen cocktails for detecting bovine tuberculosis in BCG-vaccinated cattle in natural settings.Scientific reports · 2025Article
- Effects of different vaccination regimes on the immunodiagnosis of tuberculosis in goats and evaluation of defined antigens.Frontiers in veterinary science · 2024Article
- Article
- Review of Diagnostic Tests for Detection ofFrontiers in veterinary science · 2021Review
- Potential Diagnostic Value of the Peripheral Blood Mononuclear Cell Transcriptome From Cattle With Bovine Tuberculosis.Frontiers in veterinary science · 2020Article
- Interleukin 8 and Pentaxin (C-Reactive Protein) as Potential New Biomarkers of Bovine Tuberculosis.Journal of clinical microbiology · 2019Article
- Modeling the Accuracy of TwoFrontiers in veterinary science · 2019Article
- Limitations of Using IL-17A and IFN-γ-Induced Protein 10 to Detect Bovine Tuberculosis.Frontiers in veterinary science · 2018Article
- Development and evaluation of an interferon gamma assay for the diagnosis of tuberculosis in red deer experimentally infected with Mycobacterium bovis.BMC veterinary research · 2017Article
- Tuberculosis Detection in Paratuberculosis Vaccinated Calves: New Alternatives against Interference.PloS one · 2017Article
- Evaluation of cocktails with recombinant proteins of Mycobacterium bovis for a specific diagnosis of bovine tuberculosis.BioMed research international · 2014Article
- Function and Potentials of M. tuberculosis Epitopes.Frontiers in immunology · 2014Review
- Assessment of a protein cocktail-based skin test for bovine tuberculosis in a double-blind field test in cattle.Clinical and vaccine immunology : CVI · 2013Article
- An epidemiological perspective on bovine tuberculosis spotlighting facts and dilemmas in Iran, a historically zebu-dominant farming country.Iranian journal of microbiology · 2013Article
- Vaccination with a BCG strain overexpressing Ag85B protects cattle against Mycobacterium bovis challenge.PloS one · 2012Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mycobacterial immunodominant ESAT-6 and CFP-10 antigens are strongly recognizable in tuberculosis-infected cattle, and they do not elicit a response in cattle without infection. In addition, they are absent in most environmental mycobacterial species, and therefore, their use can be an alternative to purified protein derivative (PPD) tuberculin in the development of a more specific skin diagnostic test in cattle. The aim of the current study was to assess the potential of an ESAT-6 and CFP-10 (E6-C10) protein cocktail in a skin test format in naturally tuberculosis-infected and paratuberculosis-infected cattle. We also included MPB83 as a third component in one of the protein cocktail preparations. The protein cocktail was tested at different dose concentrations (5, 10, and 15 μg per protein). The best skin response to the E6-C10 protein cocktail was obtained with 10 μg. Subsequently, this concentration was tested in 2 herds with high and low bovine tuberculosis prevalence, the latter with paratuberculosis coinfection. Our data show that the E6-C10 cocktail allows identification of an important proportion of animals that PPDB is not able to recognize, especially in low-prevalence herds. The protein cocktail did not induce reactions in tuberculosis-free cattle or in paratuberculosis-infected cattle. Addition of MPB83 to the protein cocktail did not make any difference in the skin reaction.
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