Trial reportInternational journal of methods in psychiatric research2012
Genetic Risk and Outcome of Psychosis (GROUP), a multi-site longitudinal cohort study focused on gene-environment interaction: objectives, sample characteristics, recruitment and assessment methods.
Trial report in International journal of methods in psychiatric research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
109 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The association between attachment insecurity and negative symptoms in clinical and non-clinical populations: A systematic review and meta-analysis.Psychology and psychotherapy · 2026Pooled it
- Use of illicit substances and violent behaviour in psychotic disorders: two nationwide case-control studies and meta-analyses.Psychological medicine · 2020Pooled it
- The relationship between insecure attachment and paranoia in psychosis: A systematic literature review.The British journal of clinical psychology · 2020Pooled it
- Childhood premorbid adjustment as a marker for 20-year impairments in schizophrenia spectrum disorder: results from the OPUS study.European child & adolescent psychiatry · 2026Trial
- The Transdiagnostic Association Between Childhood Trauma and Accelerated Brain Aging in Two Independent Datasets.Schizophrenia bulletin · 2026Article
- Clusters of social and substance use-related risks are associated with the duration of untreated psychosis.Psychological medicine · 2026Article
- Reward-Related Brain Function as an Endophenotype in the Mood-Psychosis Spectrum.Biological psychiatry global open science · 2026Article
- Unraveling reward processing in schizophrenia and bipolar disorder: a multilevel examination of the positive valence system.Psychological medicine · 2026Article
- Social Isolation and Aging health in Schizophrenia spectrum disorders (SIAS): study protocol for a multinational longitudinal study.BMC psychiatry · 2026Article
- C-reactive protein polygenic risk is associated with obesity-related traits in schizophrenia spectrum disorders.Frontiers in psychiatry · 2026Article
- Exploring the interplay among smoking, stress, and negative affect in patients with psychosis: An experience sampling method study.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Interrelationships of long-term changes in recovery domains among patients with schizophrenia spectrum disorders: a six-year follow-up study.BMC psychiatry · 2025Article
- Exploring the Interactions Between Psychotic Symptoms, Cognition, and Environmental Risk Factors: A Bayesian Analysis of Networks.Schizophrenia bulletin · 2025Article
- Heterogeneity of morphometric similarity networks in health and schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Engaging, recruiting, and retaining pregnant people from marginalized communities in environmental health cohort studies: a scoping review.BMC public health · 2025Article
- Autoantibodies against myelin oligodendrocyte glycoprotein in a subgroup of patients with psychotic symptoms.Frontiers in neurology · 2025Article
- A Cross-sectional Conceptual Replication and Longitudinal Evaluation of the PANSS-Autism-Severity-Score Measure Suggests it Does Not Capture Autistic Traits in Individuals With Psychosis.Schizophrenia bulletin · 2024Article
- Clinical effects of CYP2D6 phenoconversion in patients with psychosis.Journal of psychopharmacology (Oxford, England) · 2024Article
- UnidentifiedJournal of psychopharmacology (Oxford, England) · 2024Article
- Unmet Financial Needs of People with Psychotic Disorders-A Cross-Sectional Study in People with Psychotic Disorders, Parents, Siblings, and Controls.Journal of clinical medicine · 2024Article
49 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveA longitudinal focus on gene-environment vulnerability and resilience in both patients, their unaffected family members and non-related controls offers the opportunity to elucidate etiological and pathogenetic factors influencing the onset and course of psychotic disorders. The current paper delineates the objectives, sample characteristics, recruitment and assessment procedures of the Genetic Risk and Outcome of Psychoses (GROUP) study.
methodsA naturalistic longitudinal cohort study with assessments at baseline, after three and six years of follow-up. The study is conducted by a consortium of four university psychiatric centres, with their affiliated mental health care institutions in the Netherlands covering more than 7.5 million inhabitants. Extensive assessment of genetic factors, environmental factors, (endo)phenotypes, and outcome.
resultsAt baseline, 1120 patients, 1057 siblings, 919 parents and 590 healthy controls were included.
conclusionThe GROUP study will contribute to insight in risk and protective factors in the aetiology of non-affective psychotic disorders, and in the variation in their course and outcome.
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