SynthesisThe Cochrane database of systematic reviews2012
Glutamine supplementation to prevent morbidity and mortality in preterm infants.
Synthesis in The Cochrane database of systematic reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Glutamine supplementation to prevent morbidity and mortality in preterm infants.The Cochrane database of systematic reviews · 2016Pooled it
- Glutamine supplementation for young infants with severe gastrointestinal disease.The Cochrane database of systematic reviews · 2014Pooled it
- The Role of Nutrition in the Prevention and Management of Bronchopulmonary Dysplasia: A Literature Review and Clinical Approach.International journal of environmental research and public health · 2021Review
- Dietary supplementary glutamine and L-carnitine enhanced the anti-cold stress of Arbor Acres broilers.Archives animal breeding · 2021Article
- Gestational Diabetes Mellitus Changes the Metabolomes of Human Colostrum, Transition Milk and Mature Milk.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Effect of enteral glutamine supplementation for low-birth-weight infants on weight gain patterns and levels of fecal secretory immunoglobulin A.Turk pediatri arsivi · 2018Article
- Comparative Effectiveness of Prophylactic Therapies for Necrotizing Enterocolitis in Preterm Infants: Protocol for a Network Meta-analysis of Randomized Trials.International journal of preventive medicine · 2018Article
- Infant Maturity at Birth Reveals Minor Differences in the Maternal Milk Metabolome in the First Month of Lactation.The Journal of nutrition · 2015Article
- Impact of nutrition on brain development and its neuroprotective implications following preterm birth.Pediatric research · 2015Review
- Evidence-based feeding strategies before and after the development of necrotizing enterocolitis.Expert review of clinical immunology · 2014Review
- Pathophysiology and current management of necrotizing enterocolitis.Indian journal of pediatrics · 2014Review
- Amniotic fluid-borne hepatocyte growth factor protects rat pups against experimental necrotizing enterocolitis.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlutamine is a conditionally essential amino acid. Endogenous biosynthesis may be insufficient for tissue needs in states of metabolic stress. Evidence exists that glutamine supplementation improves clinical outcomes in critically ill adults. It has been suggested that glutamine supplementation may also benefit preterm infants.
objectivesTo determine the effects of glutamine supplementation on mortality and morbidity in preterm infants. SEARCH
methodsWe used the standard search strategy of the Cochrane Neonatal Review Group. This included searches of the Cochrane Central Register of Controlled Trials (The Cochrane Library, 2011, Issue 4), MEDLINE, EMBASE and CINAHL (to November 2011), conference proceedings and previous reviews. SELECTION CRITERIA: Randomised or quasi-randomised controlled trials that compared glutamine supplementation versus no glutamine supplementation in preterm infants at any time from birth to discharge from hospital. DATA COLLECTION AND ANALYSIS: We extracted data using the standard methods of the Cochrane Neonatal Review Group, with separate evaluation of trial quality and data extraction by two review authors. We synthesised data using a fixed-effect model and reported typical relative risk, typical risk difference and weighted mean difference. MAIN
resultsWe identified 11 randomised controlled trials in which a total of 2771 preterm infants participated. Five trials assessed enteral glutamine supplementation and six trials assessed parenteral glutamine supplementation. The trials were generally of good methodological quality. Meta-analysis did not detect a statistically significant effect of glutamine supplementation on mortality [typical relative risk 0.98 (95% confidence interval 0.80 to 1.18); risk difference 0.00 (95% confidence interval -0.03 to 0.02)] or major neonatal morbidities including the incidence of invasive infection or necrotising enterocolitis. Two trials that assessed neurodevelopmental outcomes at 18 to 24 months did not find any statistically significant differences in various assessments. AUTHORS'
conclusionsThe available trial data do not provide evidence that glutamine supplementation confers important benefits for preterm infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.