Evidence map›Paper›PMID 22419224›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2012

Automatic alignment of myocardial perfusion PET and 64-slice coronary CT angiography on hybrid PET/CT.

Ryo Nakazato, Damini Dey, Erick Alexánderson, Aloha Meave, Moisés Jiménez, Edgar Romero, Rodrigo Jácome, Marco Peña, Daniel S Berman, Piotr J Slomka

Abstract read
In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Utility ofCirculation. Cardiovascular imaging · 2025
    Trial
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Prognostic Value of Coronary Flow Capacity byCirculation. Cardiovascular imaging · 2024
    Article
  7. Article
  8. Prediction of outcome byJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  9. Clinical significance of corrected relative flow reserve derived fromJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  10. Combined evaluation of regional coronary artery calcium and myocardial perfusion byEuropean journal of nuclear medicine and molecular imaging · 2020
    Article
  11. Article
  12. Hybrid quantitative imaging: Will it enter clinical practice?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018
    Article
  13. Combined evaluation of regional coronary artery calcium and myocardial perfusion byEuropean journal of nuclear medicine and molecular imaging · 2018
    Article
  14. Arterial COJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2017
    Article
  15. The role of PET quantification in cardiovascular imaging.Clinical and translational imaging · 2014
    Article
  16. Myocardial perfusion imaging with PET.Imaging in medicine · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ryo NakazatoDepartment of Imaging, and Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Damini Dey
Erick Alexánderson
Aloha Meave
Moisés Jiménez
Edgar Romero
Rodrigo Jácome
Marco Peña
Daniel S Berman
Piotr J Slomka

Funding

Quantitative Prediction of Disease and Outcomes from Next Generation SPECT and CTR01HL089765 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI SLOMKA, PIOTR J · 2007 to 2021
$6.1M
NHLBI NIH HHS R01 HL089765
6 · The paper itself

Abstract

backgroundHybrid PET/CT allows for acquisition of cardiac PET and coronary CT angiography (CCTA) in one session. However, PET and CCTA are acquired with differing breathing protocols and require software registration. We aimed to validate automatic correction for breathing misalignment between PET and CCTA acquired on hybrid scanner.

methodsSingle-session hybrid PET/CT studies of rest/stress (13)N-ammonia PET and CCTA in 32 consecutive patients were considered. Automated registration of PET left ventricular (LV) surfaces with CCTA volumes was evaluated by comparing with expert manual alignment by two observers.

resultsThe average initial misalignments between the position of LV on PET and CCTA were 27.2 ± 11.8, 13.3 ± 11.5, and 14.3 ± 9.1 mm in x, y, and z axes on rest, and 26.3 ± 10.2, 11.1 ± 9.5, and 11.7 ± 7.1 mm in x, y, and z axes on stress, respectively. The automated PET-CCTA co-registration had 95% agreement as judged visually. Compared with expert manual alignment, the translation errors of the algorithm were 5.3 ± 2.8 mm (rest) and 6.0 ± 3.5 mm (stress). 3D visualization of combined coronary vessel anatomy and hypoperfusion from PET could be made without further manual adjustments.

conclusionSoftware co-registration of CCTA and PET myocardial perfusion imaging on hybrid PET/CT scanners is necessary, but can be performed automatically, facilitating integrated 3D display on PET/CT.

Indexed as

Positron-Emission TomographySubtraction TechniqueTomography, X-Ray ComputedAlgorithmsCoronary AngiographyCoronary Artery DiseaseFemaleHumansImage EnhancementImage Interpretation, Computer-AssistedMaleMiddle AgedMultimodal ImagingMyocardial Perfusion ImagingPattern Recognition, AutomatedReproducibility of Results

Identifiers

PMID22419224
PMCPMC3527130

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.