ArticleImmunogenetics2012
Cattle MHC nomenclature: is it possible to assign sequences to discrete class I genes?
Article in Immunogenetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- More than Three Decades of Bm86: What We Know and Where to Go.Pathogens (Basel, Switzerland) · 2023Review
- Article
- Development of a Potential Yeast-Based Vaccine Platform forFrontiers in immunology · 2021Article
- The IPD Project: a centralised resource for the study of polymorphism in genes of the immune system.Immunogenetics · 2020Review
- Allelic nomenclature for the duplicated MHC class II DQ genes in sheep.Immunogenetics · 2019Article
- Molecular and Antigenic Properties of Mammalian Cell-ExpressedFrontiers in immunology · 2019Article
- Comparative MHC nomenclature: report from the ISAG/IUIS-VIC committee 2018.Immunogenetics · 2018Article
- IPD-MHC 2.0: an improved inter-species database for the study of the major histocompatibility complex.Nucleic acids research · 2017Article
- Rapid identification of bovine MHCI haplotypes in genetically divergent cattle populations using next-generation sequencing.Immunogenetics · 2016Article
- A novel RNAseq-assisted method for MHC class I genotyping in a non-model species applied to a lethal vaccination-induced alloimmune disease.BMC genomics · 2016Article
- The assembly and characterisation of two structurally distinct cattle MHC class I haplotypes point to the mechanisms driving diversity.Immunogenetics · 2015Article
- The IPD and IMGT/HLA database: allele variant databases.Nucleic acids research · 2015Article
- IPD--the Immuno Polymorphism Database.Nucleic acids research · 2013Article
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Authors and funding
6 authors.
Funding
Abstract
The cattle major histocompatibility complex (MHC) region contains a variable number of classical class I genes encoding polymorphic molecules involved in antigen presentation. Six classical class I genes have been described, but assigning sequences to these genes has proved problematic. We propose a refinement of the existing nomenclature, which currently names the 97 known classical class I sequences in a single series. Phylogenetic analysis of the 3' portion of the coding region allows segregation of these into six groups; thus, we have prefixed existing names with the appropriate number. Although it is clear that some of these groups correspond to discrete genes, it is currently not possible to state definitively that all do. However, the main groupings are consistent, and in conjunction with other evidence, we feel it is now appropriate to rename the sequences accordingly. Segregation of sequences into groups in this way will facilitate ongoing research and future use of the cattle MHC section of the Immuno Polymorphism Database.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.