ArticleEpigenetics2012
Prenatal antiepileptic exposure associates with neonatal DNA methylation differences.
Article in Epigenetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Prenatal medication exposure and epigenetic outcomes: a systematic literature review and recommendations for prenatal pharmacoepigenetic studies.Epigenetics · 2022Pooled it
- Antidepressant medication during pregnancy and epigenetic changes in umbilical cord blood: a systematic review.Clinical epigenetics · 2016Pooled it
- Integrated Pharmacoepigenomic Analysis Uncovers the Impact of Antiseizure Medications on Developmental Pathways and the Protective Effect of Folic Acid.International journal of molecular sciences · 2025Article
- Article
- Sexually dimorphic methylation patterns characterize the placenta and blood from extremely preterm newborns.BMC biology · 2023Article
- The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities.IBRO neuroscience reports · 2022Review
- Prdm6 controls heart development by regulating neural crest cell differentiation and migration.JCI insight · 2022Article
- Antiseizure medication in early nervous system development. Ion channels and synaptic proteins as principal targets.Frontiers in pharmacology · 2022Review
- Elevated methylation of the vault RNA2-1 promoter in maternal blood is associated with preterm birth.BMC genomics · 2021Article
- Maternal Trauma Exposure and Childhood Anxiety Outcomes: Examining Psychosocial Mechanisms of Risk.Journal of abnormal child psychology · 2019Article
- An epigenetic clock for gestational age at birth based on blood methylation data.Genome biology · 2016Article
- DNA cytosine hydroxymethylation levels are distinct among non-overlapping classes of peripheral blood leukocytes.Journal of immunological methods · 2016Article
- Review
- The genomics of prematurity in an era of more precise clinical phenotyping: A review.Seminars in fetal & neonatal medicine · 2016Review
- A Molecular Perspective on Procedures and Outcomes with Assisted Reproductive Technologies.Cold Spring Harbor perspectives in medicine · 2016Review
- Preschool outcomes following prenatal serotonin reuptake inhibitor exposure: differences in language and behavior, but not cognitive function.The Journal of clinical psychiatry · 2016Article
- Epigenetic Signatures as Biomarkers of Exposure.Current environmental health reports · 2015Review
- An Update on Maternal Use of Antiepileptic Medications in Pregnancy and Neurodevelopment Outcomes.Journal of pediatric genetics · 2015Review
- Infant peripheral blood repetitive element hypomethylation associated with antiretroviral therapy in utero.Epigenetics · 2015Article
- Effects of antiepileptic drug monotherapy on one-carbon metabolism and DNA methylation in patients with epilepsy.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Antiepileptic drugs (AEDs) are used to treat a variety of neuropsychiatric illnesses commonly encountered in women during their reproductive years, including epilepsy and bipolar disorder. Despite their widespread use, the impact of prenatal exposure on fetal development remains obscure. To evaluate whether AEDs taken by pregnant mothers influence DNA methylation patterns in their neonates, DNA was extracted from the umbilical cord blood of 201 neonates whose mothers were treated for neuropsychiatric illness during pregnancy and interrogated across 27,578 CpG sites using the Illumina HumanMethylation27 BeadChip. The association of each methylation value with the cumulative duration of prenatal AED exposure was examined using a linear mixed model. The average methylation level across all CpG sites was calculated for each subject, and this global methylation measure was evaluated similarly. Neonates with a longer duration of AED exposure in pregnancy showed a decrease in average global methylation (p = 0.0045). Further, DNA methylation of CpG sites in 14 genes significantly decreased with the duration of prenatal AED exposure even after adjusting for multiple comparisons (FDR < 0.05). For a small subset (n = 19) of these neonates, a second tissue, placenta, was available in addition to cord blood. Methylation of 3 of these 14 CpG sites was also significantly decreased in placental tissue. These novel data suggest decreased DNA methylation in neonates of mothers who took AEDs during pregnancy. The long-term stability and potential impact of these changes warrant further attention, and caution may be warranted before prescribing AEDs to pregnant women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.