Evidence map›Paper›PMID 22418981›Full record

Trial reportKidney international2012

Increased dietary sodium is independently associated with greater mortality among prevalent hemodialysis patients.

Finnian R Mc Causland, Sushrut S Waikar, Steven M Brunelli

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Kidney international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 5 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 5 syntheses or guidelines pooled it, 111 citations in OpenAlex.

  1. Guideline
  2. Guideline
  3. Pooled it
  4. Pooled it
  5. Guideline
  6. Trial
  7. Trial
  8. Uptake of Dietary Sodium Restriction by Overweight and Obese Patients After Cardiac Revascularization.Rehabilitation nursing : the official journal of the Association of Rehabilitation Nurses
    Trial
  9. Article
  10. Review
  11. Review
  12. Article
  13. Modification of Dialysate NaKidney international reports · 2024
    Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Sodium Intake and Chronic Kidney Disease.International journal of molecular sciences · 2020
    Review
  20. Sodium, volume and pressure control in haemodialysis patients for improved cardiovascular outcomes.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Finnian R Mc CauslandRenal Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Sushrut S Waikar
Steven M Brunelli
Brigham and Women's Hospital · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Blood pressure variability and cardiovascular disease in hemodialysis patientsK23DK079056 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BRUNELLI, STEVEN · 2008 to 2012
$695k
Determinants of the Incidence and Outcome of Acute Renal FailureK23DK075941 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI WAIKAR, SUSHRUT S. · 2007 to 2011
$680k
NCRR NIH HHS UL1 RR025758NIDDK NIH HHS DK075941NIDDK NIH HHS DK079056NIDDK NIH HHS K23 DK075941NIDDK NIH HHS K23 DK079056
6 · The paper itself

Abstract

Dietary sodium is thought to play a major role in the pathogenesis of hypertension, hypervolemia, and mortality in hemodialysis patients; hence, sodium restriction is almost universally recommended. Since the evidence upon which to base these assumptions is limited, we undertook a post-hoc analysis of 1770 patients in the Hemodialysis Study with available dietary, clinical, and laboratory information. Within this cohort, 772 were men, 1113 black, and 786 diabetic, with a mean age of 58 years and a median dietary sodium intake of 2080 mg/day. After case-mix adjustment, linear regression modeling found that higher dietary sodium was associated with a greater ultrafiltration requirement, caloric and protein intake; sodium to calorie intake ratio was associated with a greater ultrafiltration requirement; and sodium to potassium ratio was associated with higher serum sodium. No indices were associated with the pre-dialysis systolic blood pressure. Cox regression modeling found that higher baseline dietary sodium and the ratio of sodium to calorie or potassium were each independently associated with greater all-cause mortality. No association between a prescribed dietary sodium restriction and mortality were found. Thus, higher reported dietary sodium intake is independently associated with greater mortality among prevalent hemodialysis patients. Randomized trials will be necessary to determine whether dietary sodium restriction improves survival.

Indexed as

AdultAgedBiomarkersBlood PressureBlood VolumeChi-Square DistributionDietary ProteinsDiet, Sodium-RestrictedEnergy IntakeFemaleHumansHypertensionKidney DiseasesLinear ModelsMaleMiddle AgedBiomarkersDietary ProteinsPotassiumSodium, Dietary

Identifiers

PMID22418981
PMCPMC3779624
OpenAlexW2076598155

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.