Evidence map›Paper›PMID 22418940›Full record

ArticleThe Journal of investigative dermatology2012

Mediator1: an important intermediary of vitamin D receptor-regulated epidermal function and hair follicle biology.

Wendy B Bollag

Abstract readComment
PubMed Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Skin changes after bariatric surgery.Anais brasileiros de dermatologia
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Wendy B BollagCharlie Norwood VA Medical Center, Georgia Health Sciences University, Augusta, Georgia 30912, USA. wbollag@georgiahealth.edu

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Considerable data in the literature support the idea that 1,25-dihydroxyvitamin D3 and the vitamin D receptor (VDR) are involved in regulating skin biology. Studies using cultured keratinocytes, artificial human skin, and transgenic mouse models, as well as observations in patients with rickets, provide evidence of this pathway's importance in epidermal proliferation and differentiation and the hair growth cycle. The report by Oda et al. in this issue also indicates an important role of the VDR coactivator mediator 1 in these processes.

Indexed as

Gene DeletionAlopeciaAnimalsCell CycleEpidermisFemaleHair FollicleKeratinocytesMaleMediator Complex Subunit 1Med1 protein, mouseMediator Complex Subunit 1

Identifiers

PMID22418940

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.