Evidence map›Paper›PMID 22418934›Full record

ArticleJournal of structural and functional genomics2012

phenix.mr_rosetta: molecular replacement and model rebuilding with Phenix and Rosetta.

Thomas C Terwilliger, Frank Dimaio, Randy J Read, David Baker, Gábor Bunkóczi, Paul D Adams, Ralf W Grosse-Kunstleve, Pavel V Afonine, Nathaniel Echols

Abstract read
In one paragraph

Article in Journal of structural and functional genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed.

  1. Article
  2. ACS chemical biology · 2025
    Article
  3. The structure of the Gemella haemolysans M26 IgA1 protease trypsin-like domain.Acta crystallographica. Section F, Structural biology communications · 2025
    Article
  4. Article
  5. AlphaFold-guided molecular replacement for solving challenging crystal structures.Acta crystallographica. Section D, Structural biology · 2025
    Article
  6. Review
  7. Article
  8. Biochemical and X-ray analyses of the players involved in the faRel2/aTfaRel2 toxin-antitoxin operon.Acta crystallographica. Section F, Structural biology communications · 2023
    Article
  9. Article
  10. Article
  11. Crystal structures of glutamyl-tRNA synthetase from Elizabethkingia anopheles and E. meningosepticum.Acta crystallographica. Section F, Structural biology communications · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Implications of AlphaFold2 for crystallographic phasing by molecular replacement.Acta crystallographica. Section D, Structural biology · 2022
    Review
  17. Article
  18. Article
  19. Article
  20. Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thomas C TerwilligerLos Alamos Institutes and BioScience Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA. terwilliger1@earthlink.net
Frank Dimaio
Randy J Read
David Baker
Gábor Bunkóczi
Paul D Adams
Ralf W Grosse-Kunstleve
Pavel V Afonine
Nathaniel Echols

Funding

PROJECT 5 - DUKE - STRUCTURE VALIDATION AND IMPROVEMENT FOR PROTEINS AND N. ACIDSP01GM063210 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI ADAMS, PAUL DAVID · 2001 to 2021
$33.5M
High resolution structure modeling with RosettaR01GM092802 · NIGMS · UNIVERSITY OF WASHINGTON · PI BAKER, DAVID · 2010 to 2017
$2.3M
NIGMS NIH HHS P01 GM063210NIGMS NIH HHS R01 GM092802Wellcome Trust 082961
6 · The paper itself

Abstract

The combination of algorithms from the structure-modeling field with those of crystallographic structure determination can broaden the range of templates that are useful for structure determination by the method of molecular replacement. Automated tools in phenix.mr_rosetta simplify the application of these combined approaches by integrating Phenix crystallographic algorithms and Rosetta structure-modeling algorithms and by systematically generating and evaluating models with a combination of these methods. The phenix.mr_rosetta algorithms can be used to automatically determine challenging structures. The approaches used in phenix.mr_rosetta are described along with examples that show roles that structure-modeling can play in molecular replacement.

Indexed as

AlgorithmsModels, MolecularProtein ConformationSoftwareComputational BiologyCrystallography, X-RayDatabases, ProteinInternetMacromolecular SubstancesMagnetic Resonance SpectroscopyProteinsProteomicsMacromolecular SubstancesProteins

Identifiers

PMID22418934
PMCPMC3375004

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.