ArticleMolecules (Basel, Switzerland)2012
Biodegradability and biocompatibility study of poly(chitosan-g-lactic acid) scaffolds.
Article in Molecules (Basel, Switzerland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Candidate Bioinks for Extrusion 3D Bioprinting-A Systematic Review of the Literature.Frontiers in bioengineering and biotechnology · 2021Pooled it
- Possible Diagnostic and Therapeutic Applications of Bioprinting for Bone Regeneration in Maxillofacial Surgery.Diagnostics (Basel, Switzerland) · 2025Review
- The Properties and Applicability of Bioprinting in the Field of Maxillofacial Surgery.Bioengineering (Basel, Switzerland) · 2025Review
- Asiaticoside-Loaded Multifunctional Bioscaffolds for Enhanced Hyperglycemic Wound Healing.Biomedicines · 2025Review
- pH-influenced self-assembled stealth nanoscaffolds encapsulating memantine for treatment of Alzheimer's disease.Journal of biosciences · 2023Article
- Quercetin-solid lipid nanoparticle-embedded hyaluronic acid functionalized hydrogel for immunomodulation to promote bone reconstruction.Regenerative biomaterials · 2023Article
- Development and Characterization of Functional Polylactic Acid/Chitosan Porous Scaffolds for Bone Tissue Engineering.Polymers · 2022Article
- Polysaccharide-Based Membrane Biocompatibility Study ofMaterials (Basel, Switzerland) · 2022Article
- Dendritic cell biocompatibility of ether-based urethane films.Journal of applied toxicology : JAT · 2021Article
- Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing.International journal of molecular sciences · 2021Review
- Chitosan Nanoparticles for Antiviral Drug Delivery: A Novel Route for COVID-19 Treatment.International journal of nanomedicine · 2021Review
- Biodegradable Chitosan-Polymers · 2020Article
- Aligned microchannel polymer-nanotube composites for peripheral nerve regeneration: Small molecule drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2019Article
- Biological Compatibility of a Polylactic Acid Composite Reinforced with Natural Chitosan Obtained from Shrimp Waste.Materials (Basel, Switzerland) · 2018Article
- Polymeric scaffolds for three-dimensional culture of nerve cells: a model of peripheral nerve regeneration.MRS communications · 2017Article
- Chitin-Based Anisotropic Nanostructures of Butterfly Wings for Regulating Cells Orientation.Polymers · 2017Article
- Fabrication of Porous Materials from Natural/Synthetic Biopolymers and Their Composites.Materials (Basel, Switzerland) · 2016Review
- Current Status of Bioinks for Micro-Extrusion-Based 3D Bioprinting.Molecules (Basel, Switzerland) · 2016Review
- Mercury(II) removal with modified magnetic chitosan adsorbents.Molecules (Basel, Switzerland) · 2013Article
- Functional enhancement of chitosan and nanoparticles in cell culture, tissue engineering, and pharmaceutical applications.Frontiers in physiology · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A biodegradable, biocompatible poly(chitosan-g-lactic acid) (PCLA) scaffold was prepared and evaluated in vitro and in vivo. The PCLA scaffold was obtained by grafting lactic acid (LA) onto the amino groups on chitosan (CS) without a catalyst. The PCLA scaffolds were characterized by Fourier Transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The biodegradabilty was determined by mass loss in vitro, and degradation in vivo as a function of feed ratio of LA/CS. Bone marrow mesenchymal stem cell (BMSC) culture experiments and histological examination were performed to evaluate the PCLA scaffolds' biocompatibility. The results indicated that PCLA was promising for tissue engineering application.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.