ReviewMolecules (Basel, Switzerland)2012
Cancer chemoprevention by carotenoids.
Review in Molecules (Basel, Switzerland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 166 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
166 citing papers in PubMed, 3 syntheses or guidelines pooled it, 577 citations in OpenAlex.
- Passion fruit (Frontiers in nutrition · 2024Pooled it
- Association of Retinol and Carotenoids Content in Diet and Serum With Risk for Colorectal Cancer: A Meta-Analysis.Frontiers in nutrition · 2022Pooled it
- Microalgae-Derived Pigments: A 10-Year Bibliometric Review and Industry and Market Trend Analysis.Molecules (Basel, Switzerland) · 2020Pooled it
- Lycopene, Carotenoids, and Retinoids in Cancer Chemoprevention: Molecular Mechanisms and Clinical Implications.Nutrients · 2026Review
- Green Extraction of Natural Antioxidants from Agro-Food and Marine Bioresources Using Vegetable Oils.Antioxidants (Basel, Switzerland) · 2026Review
- Advances in Synthetic Strategies for Microalgal Carotenoid Enhancement and Emerging Applications.Antioxidants (Basel, Switzerland) · 2026Review
- Deciphering the cancer chemopreventive potential of phytochemicals: an integrative perspective on molecular targets and signaling networks.Cancer cell international · 2026Review
- Dietary pattern modifies associations between dietary factors and pace of epigenetic aging.Frontiers in nutrition · 2026Article
- Article
- Liposomal co-delivery of β-carotene and doxorubicin for enhanced colorectal-cancer therapy.Scientific reports · 2025Article
- Positively charged liposomal β-carotene enhances irradiation-induced cytotoxicity against prostate carcinoma cells: an in-vitro study.BMC cancer · 2025Article
- Intake of total and selected carotenoids and colorectal cancer risk: An Italian case-control study.European journal of clinical nutrition · 2025Article
- Mammary tissue microbiome analysis in PyMT mice reveals Methylobacteria as a commensal organism with potential therapeutic applications.Translational oncology · 2025Article
- Correlations between Aging, Telomeres, and Natural Compounds.Aging and disease · 2025Review
- Continuous Valorization of Carbon Dioxide into the Fine Chemical Ectoine byEnvironmental science & technology · 2025Article
- Carotenoids for Antiaging: Nutraceutical, Pharmaceutical, and Cosmeceutical Applications.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Genetic diversity analysis of Phyllanthus acidus Skeels of north-east India: Insights from multivariate analysis.Scientific reports · 2025Article
- Impact of Paracoccus sp. EGY7 carotenoids on triple-negative breast cancer cells: invitro study.AMB Express · 2025Article
- Exploring the antioxidant and antimicrobial properties of five indigenous Kenyan plants used in traditional medicine.Scientific reports · 2025Article
- Blue Light Enhances the Antioxidant, Antimicrobial, and Antitumor Potential of the Green MicroalgaePlants (Basel, Switzerland) · 2024Article
106 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carotenoids are natural fat-soluble pigments that provide bright coloration to plants and animals. Dietary intake of carotenoids is inversely associated with the risk of a variety of cancers in different tissues. Preclinical studies have shown that some carotenoids have potent antitumor effects both in vitro and in vivo, suggesting potential preventive and/or therapeutic roles for the compounds. Since chemoprevention is one of the most important strategies in the control of cancer development, molecular mechanism-based cancer chemoprevention using carotenoids seems to be an attractive approach. Various carotenoids, such as β-carotene, a-carotene, lycopene, lutein, zeaxanthin, β-cryptoxanthin, fucoxanthin, canthaxanthin and astaxanthin, have been proven to have anti-carcinogenic activity in several tissues, although high doses of β-carotene failed to exhibit chemopreventive activity in clinical trials. In this review, cancer prevention using carotenoids are reviewed and the possible mechanisms of action are described.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.