ReviewCurrent opinion in HIV and AIDS2012
Impact of filarial infections on coincident intracellular pathogens: Mycobacterium tuberculosis and Plasmodium falciparum.
Review in Current opinion in HIV and AIDS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01547884 (Effect of Filarial Infection on Antigen-Specific Immune Responses in Latent Tuberculosis), which is not on this map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Filarial Infection on Antigen-Specific Immune Responses in Latent Tuberculosis
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Co-infection of tuberculosis and parasitic diseases in humans: a systematic review.Parasites & vectors · 2013Pooled it
- The human immunome in the post-schistosomiasis mass drug administration era.PLoS neglected tropical diseases · 2026Review
- Parasitic infection prevalence in tuberculosis patients and their household contacts in the Littoral Region of Cameroon.Parasite epidemiology and control · 2025Article
- Clinical and epidemiological features of imported loiasis in Beijing: a report from patients returned from Africa.BMC infectious diseases · 2024Article
- Molecular surveillance detects high prevalence of the neglected parasitemedRxiv : the preprint server for health sciences · 2023Article
- Excess Mortality Associated With Loiasis: Confirmation by a New Retrospective Cohort Study Conducted in the Republic of Congo.Open forum infectious diseases · 2023Article
- Application of loop mediated isothermal amplification (LAMP) assays for the detection ofFrontiers in tropical diseases · 2023Article
- Harnessing Immune Evasion Strategy of Lymphatic Filariae: A Therapeutic Approach against Inflammatory and Infective Pathology.Vaccines · 2022Review
- Characterising co-infections with Plasmodium spp., Mansonella perstans or Loa loa in asymptomatic children, adults and elderly people living on Bioko Island using nucleic acids extracted from malaria rapid diagnostic tests.PLoS neglected tropical diseases · 2022Article
- Highlighting the Relevance of CD8Frontiers in immunology · 2021Review
- Helminth Coinfection Is Associated With Enhanced Plasma Levels of Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases in Tuberculous Lymphadenitis.Frontiers in cellular and infection microbiology · 2021Article
- Article
- Parasite-bacteria interrelationship.Parasitology research · 2020Review
- Impact of Helminth Infections on Female Reproductive Health and Associated Diseases.Frontiers in immunology · 2020Review
- CD4 T Cells inFrontiers in immunology · 2020Article
- Coexistent Helminth Infection-Mediated Modulation of Chemokine Responses in Latent Tuberculosis.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Antagonistic effects of Plasmodium-helminth co-infections on malaria pathology in different population groups in Côte d'Ivoire.PLoS neglected tropical diseases · 2019Article
- CD39 and immune regulation in a chronic helminth infection: The puzzling case of Mansonella ozzardi.PLoS neglected tropical diseases · 2018Article
- Prevalence of Intestinal Parasites and Associated Factors among Pulmonary Tuberculosis Suspected Patients Attending University of Gondar Hospital, Gondar, Northwest Ethiopia.Journal of parasitology research · 2018Article
- Helminth parasites and immune regulation.F1000Research · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewTo examine the consequences of the immune modulation seen in chronic filarial infection on responses to intracellular pathogens (and their antigens) that are often co-endemic with filarial infections, namely Plasmodium and Mycobacterium tuberculosis. RECENT
findingsMuch of the recent data on filaria/mycobacteria or filaria/Plasmodium co-infection has focused on the modulation of mycobacteria-specific or malaria-specific responses by chronic filarial infection. As such, filarial infections very clearly alter the magnitude and quality of the mycobacteria-specific or malaria-specific cytokine responses, responses that have been typically associated with control of these intracellular pathogens. SUMMARY: Although phylogenetically distinct, mycobacteria and Plasmodium spp. often share the same geographical niche with filarial infections. The complex interplay between filarial parasites that are associated with immunomodulation and those microbial pathogens that require a proinflammatory or unmodulated response for their control is easily demonstrable ex vivo, but whether this interplay affects disease outcome in tuberculosis or malaria remains an open question.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.