ArticleAge and ageing2012
High-sensitivity C-reactive protein and mobility disability in older adults.
Article in Age and ageing, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Inflammatory Biomarkers and Gait Impairment in Older Adults: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Determinants and indicators of successful aging as a multidimensional outcome: a systematic review of longitudinal studies.Frontiers in public health · 2023Pooled it
- Trial
- Transitions in Functional Status and Frailty Among Post-Hospitalized COVID-19 Oldest-Old Adults: An 18-Month Follow-Up Study.Journal of clinical medicine · 2025Article
- Limited association between multimorbidity and high-sensitive C-reactive protein or gait speed in community-dwelling octogenarians - findings from the BUTTERFLY study.The journal of nutrition, health & aging · 2025Article
- The Role of High-SensitivityNutrients · 2025Article
- Association of adipose tissue inflammation and physical fitness in older adults.Immunity & ageing : I & A · 2024Article
- CRP, but not fibrinogen, is associated with gait speed as early as middle age, in females but not males.Scientific reports · 2023Article
- Association between levels of high-sensitivity C-reactive protein in plasma and freezing of gait in Parkinson's disease.Aging clinical and experimental research · 2022Article
- Inflammatory biomarkers and motoric cognitive risk syndrome: Multicohort survey.Cerebral circulation - cognition and behavior · 2022Article
- Influences of dopaminergic system dysfunction on late-life depression.Molecular psychiatry · 2022Review
- Elevated IL-6 and CRP Levels Are Associated With Incident Self-Reported Major Mobility Disability: A Pooled Analysis of Older Adults With Slow Gait Speed.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Motoric cognitive risk syndrome: Integration of two early harbingers of dementia in older adults.Ageing research reviews · 2020Review
- High ultrasensitive serum C-reactive protein may be related to freezing of gait in Parkinson's disease patients.Journal of neural transmission (Vienna, Austria : 1996) · 2019Article
- Longitudinal Relationship Between Interleukin-6 and Perceived Fatigability Among Well-Functioning Adults in Mid-to-Late Life.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Association of 10-Year C-Reactive Protein Trajectories With Markers of Healthy Aging: Findings From the English Longitudinal Study of Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- The urine albumin-creatinine ratio is a predictor for incident long-term care in a general population.PloS one · 2018Article
- Association of Family History of Exceptional Longevity With Decline in Physical Function in Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- C-reactive protein is associated with disability independently of vascular events: the Northern Manhattan Study.Age and ageing · 2017Article
- Associations Between Inflammation and Physical Function in African Americans and European Americans with Prevalent Cardiovascular Risk Factors.Journal of the American Geriatrics Society · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveto determine the association of high sensitivity C-reactive protein (HsCRP) levels with a risk of mobility disability and decline in older adults with and without vascular disease.
designprospective cohort.
settingcommunity-residing population. SUBJECTS: six hundred and twenty-four adults age 70 and older (62% women) with gait and HsCRP assessments.
main outcome measuresincident mobility disability (velocity <70 cm/s) and annual rates of decline on gait velocity.
resultselevated HsCRP levels (≥ 3 mg/l) at baseline present in 224 of the 624 eligible subjects was associated with a faster annual decline in gait velocity of 0.91 cm/s (P=0.02). Subjects with elevated HsCRP levels had increased risk of mobility disability (hazard ratio: 1.85, 95% CI: 1.09-3.14). Each one-unit increase in log HsCRP levels in the 406 subjects without prevalent mobility disability was associated with increased risk of mobility disability (hazard ratio: 1.33, 95% CI: 1.05-1.68). The association of baseline HsCRP levels with mobility disability and decline was stronger in the 224 individuals without vascular disease. The associations were not significant in the 400 subjects with vascular disease.
conclusionsHsCRP levels predict mobility disability and accelerated decline in walking speed in older adults. These associations were stronger in those without vascular disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.