ArticleJournal of the Royal Society, Interface2012
Regulation of oscillation dynamics in biochemical systems with dual negative feedback loops.
Article in Journal of the Royal Society, Interface, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- How the Structure of Signaling Regulation Evolves: Insights From an Evolutionary Model.Molecular biology and evolution · 2025Article
- Analysis of the spiking dynamics of a diode laser with dual optical feedback.Scientific reports · 2025Article
- Multi-Dimensional Analysis of Biochemical Network Dynamics Using pyDYVIPAC.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Feedback, Crosstalk and Competition: Ingredients for Emergent Non-Linear Behaviour in the PI3K/mTOR Signalling Network.International journal of molecular sciences · 2021Review
- Critical role of lipid membranes in polarization and migration of cells: a biophysical view.Biophysical reviews · 2021Review
- A Quantitative Modular Modeling Approach Reveals the Effects of Different A20 Feedback Implementations for the NF-kB Signaling Dynamics.Frontiers in physiology · 2020Article
- Systems and synthetic biology approaches in understanding biological oscillators.Quantitative biology (Beijing, China) · 2018Article
- Incoherent Inputs Enhance the Robustness of Biological Oscillators.Cell systems · 2017Article
- Article
- Feedback, Mass Conservation and Reaction Kinetics Impact the Robustness of Cellular Oscillations.PLoS computational biology · 2016Article
- How time delay and network design shape response patterns in biochemical negative feedback systems.BMC systems biology · 2016Article
- A Statistical Approach Reveals Designs for the Most Robust Stochastic Gene Oscillators.ACS synthetic biology · 2016Article
- Understanding complexity in the HIF signaling pathway using systems biology and mathematical modeling.Journal of molecular medicine (Berlin, Germany) · 2016Review
- Anatomy of a negative feedback loop: the case of IκBα.Journal of the Royal Society, Interface · 2015Article
- DYVIPAC: an integrated analysis and visualisation framework to probe multi-dimensional biological networks.Scientific reports · 2015Article
- Article
- Nested autoinhibitory feedbacks alter the resistance of homeostatic adaptive biochemical networks.Journal of the Royal Society, Interface · 2014Article
- Analytical study of robustness of a negative feedback oscillator by multiparameter sensitivity.BMC systems biology · 2014Article
- Functional tunability of biological circuits from additional toggle switches.IET systems biology · 2013Article
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1 author.
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Abstract
Feedback controls are central to cellular regulation. Negative-feedback mechanisms are well known to underline oscillatory dynamics. However, the presence of multiple negative-feedback mechanisms is common in oscillatory cellular systems, raising intriguing questions of how they cooperate to regulate oscillations. In this work, we studied the dynamical properties of a set of general biochemical motifs with dual, nested negative-feedback structures. We showed analytically and then confirmed numerically that, in these motifs, each negative-feedback loop exhibits distinctly different oscillation-controlling functions. The longer, outer feedback loop was found to promote oscillations, whereas the short, inner loop suppresses and can even eliminate oscillations. We found that the position of the inner loop within the coupled motifs affects its repression strength towards oscillatory dynamics. Bifurcation analysis indicated that emergence of oscillations may be a strict parametric requirement and thus evolutionarily tricky. Investigation of the quantitative features of oscillations (i.e. frequency, amplitude and mean value) revealed that coupling negative feedback provides robust tuning of the oscillation dynamics. Finally, we demonstrated that the mitogen-activated protein kinase (MAPK) cascades also display properties seen in the general nested feedback motifs. The findings and implications in this study provide novel understanding of biochemical negative-feedback regulation in a mixed wiring context.
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