ArticleArthritis research & therapy2012
Effect of pregnancy on serum cytokines in SLE patients.
Article in Arthritis research & therapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Aspirin resistance in pregnancy is associated with reduced interleukin-2 (IL-2) concentrations in maternal serum: Implications for aspirin prophylaxis for preeclampsia.Pregnancy hypertension · 2024Trial
- Influence of Maternal Adipokines on Anthropometry, Adiposity, and Neurodevelopmental Outcomes of the Offspring.International journal of molecular sciences · 2024Review
- Pregnancy-specific responses to COVID-19 revealed by high-throughput proteomics of human plasma.Communications medicine · 2023Article
- Panoramic snapshot of serum soluble mediator interplay in pregnant women with convalescent COVID-19: an exploratory study.Frontiers in immunology · 2023Observational
- IL-6 and IL-8: An Overview of Their Roles in Healthy and Pathological Pregnancies.International journal of molecular sciences · 2022Review
- Pregnancy-specific responses to COVID-19 are revealed by high-throughput proteomics of human plasma.Research square · 2022Article
- Inflammatory Bowel Disease and Reproductive Health: From Fertility to Pregnancy-A Narrative Review.Nutrients · 2022Review
- A prospective cohort study providing insights for markers of adverse pregnancy outcome in older mothers.BMC pregnancy and childbirth · 2021Observational
- Maternal Serum Cytokine Concentrations in Healthy Pregnancy and Preeclampsia.Journal of pregnancy · 2021Review
- Article
- Sex and autoimmune disease: Four mechanisms pointing at women.Mediterranean journal of rheumatology · 2019Review
- Modulatory Effects of Pregnancy on Inflammatory Bowel Disease.Clinical and translational gastroenterology · 2019Review
- Acute immunomodulatory changes during controlled ovarian stimulation: evidence from the first trial investigating the short-term effects of estradiol on biomarkers and B cells involved in autoimmunity.Journal of assisted reproduction and genetics · 2015Article
- Growth modeling of the maternal cytokine milieu throughout normal pregnancy: macrophage-derived chemokine decreases as inflammation/counterregulation increases.Journal of immunology research · 2015Article
- Predictors of maternal and fetal complications in SLE patients: a prospective study.Immunologic research · 2014Article
- Clinical guidelines and definitions of autoinflammatory diseases: contrasts and comparisons with autoimmunity-a comprehensive review.Clinical reviews in allergy & immunology · 2013Review
- Clinical correlates of a subset of anti-CENP-A antibodies cross-reacting with FOXE3p53-62 in systemic sclerosis.Arthritis research & therapy · 2013Article
- New-onset systemic lupus erythematosus during pregnancy.Clinical rheumatology · 2013Article
- Management of pregnancy in systemic lupus erythematosus.Nature reviews. Rheumatology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe aim of this study was to evaluate an extensive panel of cytokines involved in immune regulation during pregnancy in patients with systemic lupus erythematosus (SLE) and in healthy women.
methodsA total of 47 consecutive successful pregnancies in 46 SLE patients and 56 pregnancies in 56 matched healthy subjects, as controls, were prospectively studied. Serum interleukin (IL)-1-α, IL-1-β, IL-2, IL-6, IL-8, IL-10, IL-12p70, interferon (INF)-γ and tumor necrosis factor (TNF)-α were detected in sera obtained at the first and third trimester of pregnancy by a highly sensitive, multiplexed sandwich ELISA.
resultsMedians (pg/ml) of serum levels of most helper T (Th)1-type cytokines were significantly lower in the third trimester compared with those observed in the first trimester of pregnancy in healthy women: INF-γ 2.0 vs 3.4, TNF-α 10.2 vs 11.5, IL-1-α 0.9 vs 1.1, IL-1-β 0.6 vs 1.0, IL-2 3.0 vs 3.5, and IL-12p70 4.9 vs 5.6 (P-values < 0.02 for all). By contrast, only the IL-1-α serum levels were lower in the third trimester compared with the first trimester in SLE patients (P = 0.006). IFN-γ/IL-6 and IFN-γ/IL-10 ratios were higher in controls than in SLE (P = 0.002, and P = 0.001, respectively); moreover, they were significantly reduced in the third compared to the first trimester of pregnancy in healthy women, but not in SLE.
conclusionsIn SLE patients, Th1/Th2 cytokine serum level ratio does not decrease during pregnancy progression as much as in healthy pregnant women. This could account for the observation of a low frequency of disease flares in the third trimester of gestation.
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Registered trials
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