Evidence map›Paper›PMID 22417701›Full record

ArticleProstaglandins, leukotrienes, and essential fatty acids2012

Cis-vaccenic acid and the Framingham risk score predict chronic kidney disease: the multi-ethnic study of atherosclerosis (MESA).

Robert Block, Lisa Kakinami, Scott Liebman, Gregory C Shearer, Holly Kramer, Michael Tsai

Abstract read
In one paragraph

Article in Prostaglandins, leukotrienes, and essential fatty acids, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Robert BlockDepartment of Community and Preventive Medicine, Division of Epidemiology, the University of Rochester School of Medicine, Rochester, NY 14642, USA. robert_block@urmc.rochester.edu
Lisa Kakinami
Scott Liebman
Gregory C Shearer
Holly Kramer
Michael Tsai
University of Rochester · USLoyola University Medical Center · USSanford Research · USUniversity of Minnesota · US

Funding

WESTCORE DNA SEQUENCING AND GENOTYPING CORE FACILITYP20RR016479 · NCRR · UNIVERSITY OF SOUTH DAKOTA · PI GOODMAN, BARBARA EASON · 2001 to 2011
$32.2M
The University of Rochester's Clinical and Translational Science InstituteKL2RR024136 · NCRR · UNIVERSITY OF ROCHESTER · PI PEARSON, THOMAS ARTHUR · 2006 to 2011
$4.3M
LPA and Edg Receptors in the Pulmonary Immune ResposeR01HL071933 · NHLBI · UNIVERSITY OF ROCHESTER · PI GEORAS, STEVE N · 2004 to 2013
$3.1M
Adjunctive Use of Apyrase to Fibrinolytic TherapyR44HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2012 to 2013
$1.3M
The Effects of Fish Oil and Aspirin on Cardiovascular Risk in Type 2 DiabetesR21HL102582 · NHLBI · UNIVERSITY OF ROCHESTER · PI BLOCK, ROBERT CHARLES · 2010 to 2011
$420k
SUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTER-N01HC95159-268095159N01HC095159 · HC · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 1999 to 2006
$304k
Adjunctive Use of Apyrase to Fibrinolytic TherapyR43HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2009 to 2009
$226k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READINGN01HC095169 · HC · LA BIOMED RES INST/ HARBOR UCLA MED CTR · PI DETRANO, ROBERT · 1999 to 2001
$124k
NCRR NIH HHS KL2 RR024136NCRR NIH HHS KL2RR024136NCRR NIH HHS P20 RR016479NCRR NIH HHS P20RR016479NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01-HC-95159NHLBI NIH HHS N01-HC-95169NHLBI NIH HHS R01 HL071933NHLBI NIH HHS R01HL071933NHLBI NIH HHS R21 HL102582
6 · The paper itself

Abstract

introductionData on the associations of fatty acids with chronic kidney disease (CKD) are sparse. MATERIALS AND

methodsWe performed a cross-sectional study of 2792 men and women from the MESA cohort of African-American, Caucasian, Chinese and Hispanic adults without known cardiovascular disease. Plasma phospholipid fatty acid proportions were associated with estimated glomerular filtration rate (eGFR) and the albumin/creatinine ratio.

resultsCis-vaccenic acid (18:1n-7), adjusted for other fatty acids using multivariate logistic regression (CI: 1.0-1.4), and step-wise logistic regression (CI: 1.02-1.42), was positively associated with reduced eGFR. The Framingham Risk Score, when adjusting for fatty acid proportions and demographic factors, was positively associated with CKD as measured by the eGFR and the albumin/creatinine ratio. DISCUSSION AND

conclusionsPlasma phospholipid proportions of the 18 carbon monounsaturated cis-vaccenic acid {18:1n-7}) and the Framingham Risk Score are associated with kidney function. The potential role of 18:1n-7 in the development of CKD warrants further investigation.

Indexed as

AgedAsianAtherosclerosisBlack or African AmericanBlack PeopleCreatinineCross-Sectional StudiesFemaleGlomerular Filtration RateHispanic or LatinoHumansKidney Failure, ChronicLogistic ModelsMaleMiddle AgedOleic Acidscis-vaccenic acidCreatinineOleic Acids

Identifiers

PMID22417701
PMCPMC3340522
OpenAlexW2086961847

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.