ArticleLymphatic research and biology2012
Concentration of indocyanine green does not significantly influence lymphatic function as assessed by near-infrared imaging.
Article in Lymphatic research and biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Key refinements to a large animal model for measurement of real-time lymphatic transport.BMC medical imaging · 2025Article
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- Optimization and use of near infrared imaging to guide lymph node collection in rhesus macaques (Macaca mulatta).Journal of medical primatology · 2022Article
- Differences in L-type CaAmerican journal of physiology. Heart and circulatory physiology · 2018Article
- Experimental Models Used to Assess Lymphatic Contractile Function.Lymphatic research and biology · 2017Review
- Optical tracer size differences allow quantitation of active pumping rate versus Stokes-Einstein diffusion in lymphatic transport.Journal of biomedical optics · 2016Article
- Near-Infrared Fluorescence Lymphatic Imaging to Reconsider Occlusion Pressure of Superficial Lymphatic Collectors in Upper Extremities of Healthy Volunteers.Lymphatic research and biology · 2016Article
- Lymphatic mapping and preoperative imaging in the management of post-mastectomy lymphoedema.Gland surgery · 2016Article
- Targeting tumor hypoxia: a third generation 2-nitroimidazole-indocyanine dye-conjugate with improved fluorescent yield.Organic & biomolecular chemistry · 2015Article
- Small portable interchangeable imager of fluorescence for fluorescence guided surgery and research.Technology in cancer research & treatment · 2015Article
- Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field.International journal of nanomedicine · 2014Review
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- Targeting tumor hypoxia with 2-nitroimidazole-indocyanine green dye conjugates.Journal of biomedical optics · 2013Article
- Differential transport function of lymphatic vessels in the rat tail model and the long-term effects of Indocyanine Green as assessed with near-infrared imaging.Frontiers in physiology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAbsorbance of near-infrared (600-800 nm) light by the tissue components water, melanin, and hemoglobin is minimal. This property allows the use of near-infrared-emitting fluorophores for noninvasive, in vivo, real-time imaging of tissue, without the interference of autofluorescence experienced with imaging in other wavelength ranges. Near-infrared (NIR) fluorescence imaging has been used to noninvasively image lymphatic architecture and pumping function in animals, as well as in humans. The effects of different doses of a NIR dye, indocyanine green (ICG), on lymphatic function have been questioned. This study aims to address these concerns in the context of a mouse inguinal-to-axillary lymphatic imaging model. METHODS AND
resultsWe measured lymph propulsive velocity and frequency using an imaging system composed of a laser diode for excitation of the dye, an image intensifier, and an intensified charge-coupled device (ICCD) camera to capture real-time images. At 0.32, 0.645, and 1.3 mM ICG, no significant differences in lymphatic propulsive velocity or frequency were observed. Additionally, the use of other NIR imaging agents did not result in significant differences.
conclusionsThe use of different concentrations of ICG and the use of other near-infrared fluorophores for optical imaging of lymphatics does not significantly affect lymphatic propulsive velocity or frequency.
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Registered trials
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