ArticleFrontiers in physiology2012
Antioxidants and Skeletal Muscle Performance: "Common Knowledge" vs. Experimental Evidence.
Article in Frontiers in physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Pooled it
- Impact of polyphenol antioxidants on cycling performance and cardiovascular function.Nutrients · 2014Trial
- Antioxidant effect of chromium picolinate on chronic exercise-induced oxidative stress in male rats.Scientific reports · 2025Article
- Nitrosative Redox Homeostasis and Antioxidant Response Defense in DisusedAntioxidants (Basel, Switzerland) · 2021Article
- Ionic Silicon Protects Oxidative Damage and Promotes Skeletal Muscle Cell Regeneration.International journal of molecular sciences · 2021Article
- Capsaicinoids improve consequences of physical activity.Toxicology reports · 2018Article
- Nicorandil improves post-fatigue tension in slow skeletal muscle fibers by modulating glutathione redox state.Journal of bioenergetics and biomembranes · 2017Article
- Omega-3 fatty acids differentially modulate enzymatic anti-oxidant systems in skeletal muscle cells.Cell stress & chaperones · 2016Article
- Effects of Exercise Training under Hyperbaric Oxygen on Oxidative Stress Markers and Endurance Performance in Young Soccer Players: A Pilot Study.Journal of nutrition and metabolism · 2016Article
- Antioxidant treatments do not improve force recovery after fatiguing stimulation of mouse skeletal muscle fibres.The Journal of physiology · 2015Article
- Potential molecular mechanisms underlying muscle fatigue mediated by reactive oxygen and nitrogen species.Frontiers in physiology · 2015Review
- Doublet discharge stimulation increases sarcoplasmic reticulum Ca2+ release and improves performance during fatiguing contractions in mouse muscle fibres.The Journal of physiology · 2013Article
- Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy.Biological chemistry · 2013Review
- Muscle fatigue and muscle weakness: what we know and what we wish we did.Frontiers in physiology · 2013Article
- Effects of physical activity and inactivity on muscle fatigue.Frontiers in physiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Antioxidants are assumed to provide numerous benefits, including better health, a reduced rate of aging, and improved exercise performance. Specifically, antioxidants are commonly "prescribed" by the media, supplement industry, and "fitness experts" for individuals prior to training and performance, with assumed benefits of improved fatigue resistance and recovery. This has provoked expansion of the supplement industry which responded by creation of a plethora of products aimed at facilitating the needs of the active individual. However, what does the experimental evidence say about the efficacy of antioxidants on skeletal muscle function? Are antioxidants actually as beneficial as the general populous believes? Or, could they in fact lead to deleterious effects on skeletal muscle function and performance? This Mini Review addresses these questions with an unbiased look at what we know about antioxidant effects on skeletal muscle, and what we still need to know before conclusions can be made.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.