Trial reportFish physiology and biochemistry2012
Dietary tryptophan changes serum stress markers, enzyme activity, and ions concentration of wild common carp Cyprinus carpio exposed to ambient copper.
Trial report in Fish physiology and biochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 67 citations in OpenAlex.
- Dietary L-tryptophan supplementation alleviates ammonia-induced stress in nile tilapia fingerlings.Scientific reports · 2025Article
- Article
- Multi biomarker approach to assess manganese and manganese nanoparticles toxicity in Pangasianodon hypophthalmus.Scientific reports · 2023Article
- Protective effects of summer savory (Satureja hortensis) oil on growth, biochemical, and immune system performance of common carp exposed to pretilachlor herbicide.Veterinary research communications · 2022Article
- Tryptophan supplementation helps totoaba (Totoaba macdonaldi) juveniles to regain homeostasis in high-density culture conditions.Fish physiology and biochemistry · 2020Article
- An acute increase in water temperature can increase free amino acid concentrations in the blood, brain, liver, and muscle in goldfish (Carassius auratus).Fish physiology and biochemistry · 2019Article
- Metabolic and Stress Responses in Senegalese Soles (Animals : an open access journal from MDPI · 2019Article
- Stressors Due to Handling Impair Gut Immunity in Meagre (Frontiers in physiology · 2019Article
- Tryptophan Metabolic Pathways and Brain Serotonergic Activity: A Comparative Review.Frontiers in endocrinology · 2019Review
- Hemolysis interference in measuring fish plasma biochemical indicators.Fish physiology and biochemistry · 2017Article
- Effects of amino acid supplementations on metabolic and physiological parameters in Atlantic cod (Gadus morhua) under stress.Fish physiology and biochemistry · 2017Article
- Serum biochemical and non-specific immune responses of rainbow trout (Oncorhynchus mykiss) to dietary nucleotide and chronic stress.Fish physiology and biochemistry · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Effect of dietary tryptophan (TRP) on copper toxicity was investigated in common carp, Cyprinus carpio. Fish were randomly distributed into two triplicate treatments (control and TRP) and fed control (TRP = 3.1 g kg(-1)) or TRP (TRP = 8.1 g kg(-1)) diets over a 2-week period. Then, both treatments were subjected to 10 mg l(-1) copper sulfate over a 7-day period. Mortality and serum cortisol, glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), sodium, potassium, and chloride levels were recorded at 0, 24, 72, 120, and 168 h post-copper exposure. There was no mortality in the TRP group, whereas the control group mortality was started at 120 h post-copper exposure (21.7 ± 7.6 %) and reached 61.7 ± 10.4 % at the end of the experiment. Cortisol, glucose, ALT, and AST levels significantly (P < 0.05) increased after copper exposure in both groups; however, the control group showed significantly higher levels than the TRP group. In both groups, sodium decreased after copper exposure and did not return to the pre-exposure values. Potassium levels significantly increased 24 h post-copper exposure in both groups and remained significantly elevated in the control group at 72 h, when fell to the pre-exposure values in the TRP group. No significant changes were observed in the chloride levels in any groups. It is concluded that dietary TRP is capable to increase common carp tolerance to copper toxicity via mitigating copper-induced stress rather than restoring gill dysfunction and hydromineral imbalance.
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