ArticleMolecular systems biology2012
Proteomic and protein interaction network analysis of human T lymphocytes during cell-cycle entry.
Article in Molecular systems biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Single cell transcriptome profiling reveals cutaneous immune microenvironment remodeling by photodynamic therapy in photoaged skin.Frontiers in immunology · 2023Article
- Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation.Cell reports · 2017Article
- Algorithms for modeling global and context-specific functional relationship networks.Briefings in bioinformatics · 2016Article
- Protein networks and activation of lymphocytes.Current opinion in immunology · 2015Review
- Anti-tumoral effects of miR-3189-3p in glioblastoma.The Journal of biological chemistry · 2015Article
- A proteomic survey of widespread protein aggregation in yeast.Molecular bioSystems · 2014Article
- Genome-wide transcriptional analysis of T cell activation reveals differential gene expression associated with psoriasis.BMC genomics · 2013Article
- From a gene-centric to whole-proteome view of differentiation of T helper cell subsets.Briefings in functional genomics · 2013Article
- Linkers of cell polarity and cell cycle regulation in the fission yeast protein interaction network.PLoS computational biology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Regulating the transition of cells such as T lymphocytes from quiescence (G(0)) into an activated, proliferating state involves initiation of cellular programs resulting in entry into the cell cycle (proliferation), the growth cycle (blastogenesis, cell size) and effector (functional) activation. We show the first proteomic analysis of protein interaction networks activated during entry into the first cell cycle from G(0). We also provide proof of principle that blastogenesis and proliferation programs are separable in primary human T cells. We employed a proteomic profiling method to identify large-scale changes in chromatin/nuclear matrix-bound and unbound proteins in human T lymphocytes during the transition from G(0) into the first cell cycle and mapped them to form functionally annotated, dynamic protein interaction networks. Inhibiting the induction of two proteins involved in two of the most significantly upregulated cellular processes, ribosome biogenesis (eIF6) and hnRNA splicing (SF3B2/SF3B4), showed, respectively, that human T cells can enter the cell cycle without growing in size, or increase in size without entering the cell cycle.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.