ArticleCurrent hypertension reports2012
Adipose tissue as regulator of vascular tone.
Article in Current hypertension reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 44 citations in OpenAlex.
- Epoprostenol up-regulates serum adiponectin level in patients with systemic sclerosis: therapeutic implications.Archives of dermatological research · 2021Trial
- Visfatin correlates with hot flashes in postmenopausal women with metabolic syndrome: effects of genistein.Endocrine · 2017Trial
- The Dual Role of Perivascular Adipose Tissue in Vascular Homeostasis and Atherogenesis: From Physiology to Pathological Implications.International journal of molecular sciences · 2025Review
- Adiponectin and gastric fundus: A potential target for gut-brain axis dysfunctions.Physiological reports · 2025Review
- Abdominal volume index is associated with higher oxidized LDL, high blood pressure and lower HDL among obese adults.BMC endocrine disorders · 2025Article
- Emerging Roles of Sympathetic Nerves and Inflammation in Perivascular Adipose Tissue.Cardiovascular drugs and therapy · 2019Review
- Adipocyte nuclei captured from VAT and SAT.BMC obesity · 2016Article
- Lean and Obese Coronary Perivascular Adipose Tissue Impairs Vasodilation via Differential Inhibition of Vascular Smooth Muscle K+ Channels.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- Adiponectin levels are reduced while markers of systemic inflammation and aortic remodelling are increased in intrauterine growth restricted mother-child couple.BioMed research international · 2014Article
- Implication of circulating omentin-1 level on the arterial stiffening in type 2 diabetes mellitus.Endocrine · 2013Article
- Maladaptive immune and inflammatory pathways lead to cardiovascular insulin resistance.Metabolism: clinical and experimental · 2013Review
- Perivascular adipose tissue potentiates contraction of coronary vascular smooth muscle: influence of obesity.Circulation · 2013Article
- Inflammatory markers should be assessed together with cardiovascular risk factors by clinicians in masked hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2013Article
- The influence of sodium- and calcium-regulatory hormone interventions on adipocytokines in obesity and diabetes.Metabolism: clinical and experimental · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adipokines secreted by visceral, subcutaneous, and perivascular adipocytes are involved in the regulation of vascular tone by acting as circulatory hormones (leptin, adiponectin, omentin, visfatin, angiotensin II, resistin, tumor necrosis factor-α, interleukin-6, apelin) and/or via local paracrine factors (perivascular adipocyte-derived relaxing and contractile factors). Vascular tone regulation by adipokines is compromised in obesitas and obesity-related disorders. Hypoxia created in growing adipose tissue dysregulates synthesis of vasoactive adipokines in favor of harmful proinflammatory adipokines, while the levels of the cardioprotective adipokines adiponectin and omentin decrease. Considering the potential of the role of adipokines in obesity-related vascular diseases, strategies to counter these diseases by targeting the adipokines are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.