Evidence map›Paper›PMID 22415364›Full record

ArticleJournal of materials science. Materials in medicine2012

Development of fibroblast culture in three-dimensional activated carbon fiber-based scaffold for wound healing.

Wen-Ying Huang, Chia-Lin Yeh, Jui-Hsiang Lin, Jai-Sing Yang, Tse-Hao Ko, Yu-Hsin Lin

Abstract readComparative StudyEvaluation Study
PubMed Publisher
In one paragraph

Article in Journal of materials science. Materials in medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Construction of Antibacterial MoSMaterials (Basel, Switzerland) · 2025
    Article
  4. Porphyrin Photosensitizers Grafted in Cellulose Supports: A Review.International journal of molecular sciences · 2023
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Wen-Ying HuangDepartment of Applied Cosmetology and Graduate Institute of Cosmetic Science, Hungkuang University, Taichung, Taiwan.
Chia-Lin Yeh
Jui-Hsiang Lin
Jai-Sing Yang
Tse-Hao Ko
Yu-Hsin Lin
China Medical University · TWFeng Chia University · TWHungkuang University · TWNano Carbon (Poland) · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This work developed a novel bi-layer wound dressing composed of 3D activated carbon fibers that allows facilitates fibroblast cell growth and migration to a wound site for tissue reconstruction, and the gentamicin is incorporated into a poly(γ-glutamic acid)/gelatin membrane to prevent bacterial infection. In an in vitro, field emission scanning electron microscopy shows that rat skin fibroblasts appeared and spread on the surface of activated carbon fibers, and penetrated the interior and exterior of the 3D activated carbon fiber construct to a depth of roughly 200 μm. An in vivo analysis shows that fibroblast cells containing the proposed 3D scaffold had the potential of a biologically functionalized dressing to accelerate wound closure. Additionally, fibroblasts migrated to the wound site in a bi-layer wound dressing containing fibroblasts, enhancing fibronectin and type I collagen expression, resulting in faster skin regeneration than that achieved with a Tegaderm™ hydrocolloid dressing or gauze.

Indexed as

CarbonTissue ScaffoldsAnimalsAnti-Bacterial AgentsBiocompatible MaterialsBiological DressingsCarbon FiberCell Culture TechniquesCell MovementCell ProliferationCells, CulturedCollagen Type IFibroblastsFibronectinsGentamicinsMaleAnti-Bacterial AgentsBiocompatible MaterialsCarbonCarbon FiberCollagen Type IFibronectinsGentamicins

Identifiers

PMID22415364
OpenAlexW1977551269

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.