ArticlePsychopharmacology2012
Altered locomotor and stereotyped responses to acute methamphetamine in adolescent, maternally separated rats.
Article in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Modeling methamphetamine use disorder in mammals: Sex differences in behavioral, biochemical, and transcriptional consequences.Advances in pharmacology (San Diego, Calif.) · 2024Article
- Communal nesting shapes the sex-dependent glutamatergic response to early life stress in the rat prefrontal cortex.Frontiers in psychiatry · 2024Article
- Sex differences in addiction-relevant behavioral outcomes in rodents following early life stress.Addiction neuroscience · 2023Article
- Sexual satiety modifies methamphetamine-induced locomotor and rewarding effects and dopamine-related protein levels in the striatum of male rats.Psychopharmacology · 2023Article
- iTat transgenic mice exhibit hyper-locomotion in the behavioral pattern monitor after chronic exposure to methamphetamine but are unaffected by Tat expression.Pharmacology, biochemistry, and behavior · 2023Article
- Communal nesting differentially attenuates the impact of pre-weaning social isolation on behavior in male and female rats during adolescence and adulthood.Frontiers in behavioral neuroscience · 2023Article
- Sex differences in methamphetamine use disorder perused from pre-clinical and clinical studies: Potential therapeutic impacts.Neuroscience and biobehavioral reviews · 2022Review
- Endocannabinoid signaling regulates the reinforcing and psychostimulant effects of ketamine in mice.Nature communications · 2020Article
- Effects of a methamphetamine vaccine, IXT-v100, on methamphetamine-related behaviors.Psychopharmacology · 2020Article
- A prior history of binge-drinking increases sensitivity to the motivational valence of methamphetamine in female C57BL/6J mice.Substance abuse : research and treatment · 2020Article
- Effects of MDPV on dopamine transporter regulation in male rats. Comparison with cocaine.Psychopharmacology · 2019Article
- Maternal care-related differences in males and females rats' sensitivity to ethanol and the associations between the GABAergic system and steroids in males.Developmental psychobiology · 2018Article
- Toll-like receptor 3 modulates the behavioral effects of cocaine in mice.Journal of neuroinflammation · 2018Article
- Protective and restorative effects of the traditional Chinese medicine Jitai tablet against methamphetamine-induced dopaminergic neurotoxicity.BMC complementary and alternative medicine · 2018Article
- Adolescence and Reward: Making Sense of Neural and Behavioral Changes Amid the Chaos.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Review
- Maternal separation increases methamphetamine-induced damage in the striatum in male, but not female rats.Behavioural brain research · 2015Article
- Arginine Methyltransferase 1 in the Nucleus Accumbens Regulates Behavioral Effects of Cocaine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The effect of early environmental manipulation on locomotor sensitivity and methamphetamine conditioned place preference reward.Behavioural brain research · 2014Article
- The snoRNA MBII-52 regulates cocaine-induced conditioned place preference and locomotion in mice.PloS one · 2014Article
- The Effects of Maternal Separation on Adult Methamphetamine Self-Administration, Extinction, Reinstatement, and MeCP2 Immunoreactivity in the Nucleus Accumbens.Frontiers in psychiatry · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
rationaleNeonatal maternal separation (MS) has been used to model the effects of early life stress in rodents. MS alters behavioral responses to a variety of abused drugs, but few studies have examined its effects on methamphetamine sensitivity.
objectivesWe sought to determine the effects of MS on locomotor and stereotyped responses to low-to-moderate doses of methamphetamine in male and female adolescent rats.
methodsMale and female rat pups were subjected to 3 h per day of MS on postnatal days (PN) 2-14 or a brief handling control procedure during the same period. During adolescence (approximately PN 40), all rats were tested for locomotor activity and stereotyped behavior in response to acute methamphetamine administration (0, 1.0, or 3.0 mg/kg, s.c.).
resultsMS rats of both sexes exhibited increased locomotor activity in a novel environment, relative to handled controls. MS increased the locomotor response to methamphetamine (METH), and this effect occurred at different doses for male (3.0 mg/kg) and female (1.0 mg/kg) rats. MS also increased stereotyped behavior in response to METH (1.0 mg/kg) in both sexes.
conclusionsMS enhances the locomotor response to METH in a dose- and sex-dependent manner. These results suggest that individuals with a history of early life stress may be particularly vulnerable to the psychostimulant effects of METH, even at relatively low doses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.