ReviewSeminars in perinatology2012
Patent ductus arteriosus: are current neonatal treatment options better or worse than no treatment at all?
Review in Seminars in perinatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
122 citing papers in PubMed, 9 syntheses or guidelines pooled it, 285 citations in OpenAlex.
- Targeted Neonatal Echocardiography in Neonatal Patent Ductus Arteriosus Management: A Systematic Review of Clinical Utility and Outcomes.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Early treatment versus expectant management of hemodynamically significant patent ductus arteriosus for preterm infants.The Cochrane database of systematic reviews · 2025Pooled it
- Fluid restriction for treatment of symptomatic patent ductus arteriosus in preterm infants.The Cochrane database of systematic reviews · 2024Pooled it
- Brain natriuretic peptide and N-terminal brain natriuretic peptide for the diagnosis of haemodynamically significant patent ductus arteriosus in preterm neonates.The Cochrane database of systematic reviews · 2022Pooled it
- Prophylactic cyclo-oxygenase inhibitor drugs for the prevention of morbidity and mortality in preterm infants: a network meta-analysis.The Cochrane database of systematic reviews · 2022Pooled it
- Factors Associated With Benefit of Treatment of Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2021Pooled it
- Early treatment versus expectant management of hemodynamically significant patent ductus arteriosus for preterm infants.The Cochrane database of systematic reviews · 2020Pooled it
- Pooled it
- Pooled it
- Patent Ductus Arteriosus, Hydrocortisone, and Outcome among Infants Born Extremely Preterm: Secondary Analysis of the Hydrocortisone Trial.The Journal of pediatrics · 2025Trial
- Effect of chest shielding during phototherapy for hyperbilirubinemia on symptomatic patent ductus arteriosus - a double-blind randomized placebo-controlled trial.Pediatric research · 2024Trial
- The effects of WeChat follow-up management to improve the parents' mental status and the quality of life of premature newborns with patent ductus arteriosus.Journal of cardiothoracic surgery · 2021Trial
- A pilot randomised blinded placebo-controlled trial of paracetamol for later treatment of a patent ductus arteriosus.Journal of perinatology : official journal of the California Perinatal Association · 2019Trial
- Factors affecting N-terminal pro-B-type natriuretic peptide levels in preterm infants and use in determination of haemodynamic significance of patent ductus arteriosus.European journal of pediatrics · 2018Trial
- Serial echocardiography in very preterm infants: a pilot randomized trial.Acta paediatrica (Oslo, Norway : 1992) · 2013Trial
- Beyond ductal closure: interpreting the TREOCAPA trial in the evolving management of patent ductus arteriosus in preterm infants.Translational pediatrics · 2026Article
- Current practices in the management of hemodynamically significant patent ductus arteriosus.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Assessment of Kidney Function and Acute Kidney Injury following Transcatheter Patent Ductus Arteriosus Closure in Preterm Infants.American journal of perinatology · 2026Article
- Caring for the smallest hearts: cardiovascular phenotypes and assessment in tiny babies.Pediatric research · 2026Review
- Comparison of early and late surgical ligation of patent ductus arteriosus in preterm infants.Medicine · 2026Article
62 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Although a moderate-sized patent ductus arteriosus (PDA) needs to be closed by the time a child is 1-2 years old, there is great uncertainty about whether it needs to be closed during the neonatal period. Although 95% of neonatologists believe that a moderate-sized PDA should be closed if it persists in infants (born before 28 weeks) who still require mechanical ventilation, the number of neonatologists who treat a PDA when it occurs in infants who do not require mechanical ventilation varies widely. Both the high likelihood of spontaneous ductus closure and the absence of randomized controlled trials, specifically addressing the risks and benefits of neonatal ductus closure, add to the current uncertainty. New information suggests that early pharmacologic treatment has several important short-term benefits for the preterm newborn. By contrast, ductus ligation, while eliminating the detrimental effects of a PDA on lung development, may create its own set of morbidities that counteract many of the benefits derived from ductus closure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.