ArticleTranscription
The binding site and mechanism of the RNA polymerase inhibitor tagetitoxin: an issue open to debate.
Article in Transcription. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Targeting Bacterial RNA Polymerase: Harnessing Simulations and Machine Learning to Design Inhibitors for Drug-Resistant Pathogens.Biochemistry · 2025Review
- Bacterial Transcription as a Target for Antibacterial Drug Development.Microbiology and molecular biology reviews : MMBR · 2016Review
- Tagetitoxin inhibits transcription by stabilizing pre-translocated state of the elongation complex.Nucleic acids research · 2013Article
- Cys-pair reporters detect a constrained trigger loop in a paused RNA polymerase.Molecular cell · 2013Article
- Response to Klyuyev and Vassylyev: on the mechanism of tagetitoxin inhibition of transcription.TranscriptionArticle
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2 authors.
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Abstract
In a recent paper in the Journal of Biological Chemistry, Artsimovitch et al. report a major revision of a crystallographic model and proposed mechanism of the RNA polymerase inhibitor, tagetitoxin. This reassessment is based on theoretical modeling using molecular dynamics simulations. Here, we argue that this theoretical model contradicts experimental results and a published crystal structure cannot exclude several mechanistically distinct alternative models and does not support some major conclusions. We conclude that understanding the tagetitoxin mechanism is beyond the reach of currently available computational simulations and must await input from high-resolution crystal structures of tagetitoxin bound to elongation complex, extensive biochemical studies, or both.
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