ReviewActa biomaterialia2012
The dentin organic matrix - limitations of restorative dentistry hidden on the nanometer scale.
Review in Acta biomaterialia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 2 syntheses or guidelines pooled it, 212 citations in OpenAlex.
- Collagen-depletion strategies in dentin as alternatives to the hybrid layer concept and their effect on bond strength: a systematic review.Scientific reports · 2022Pooled it
- Mechanisms regulating the degradation of dentin matrices by endogenous dentin proteases and their role in dental adhesion. A review.American journal of dentistry · 2014Pooled it
- Accessing Polyphenols Effect on Bond Strength and Dentin Enzymatic Degradation.Clinical and experimental dental research · 2026Article
- Hierarchically Rough rGO/HAp Nanocoatings on SLM Ti-6Al-4 V Implants for Enhanced Biointegration.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Operator Experience Does Not Affect the Reliability of Universal Adhesives' Bond Strength; Adhesive Type Does.The journal of adhesive dentistry · 2026Article
- Effects and Properties of Deproteinizing Methods in Dentin: A Comprehensive Narrative Review.Journal of functional biomaterials · 2026Review
- A novel dual-reactive primer enhances bond durability and builds chemical interlocking structures at the caries-affected dentin-biomaterial interface.Materials today. Bio · 2026Article
- A Bioinspired Approach to Mechanically Reinforce Collagen-Rich Tissues Using Modularly Defined Stilbenoids.Biopolymers · 2026Article
- Physico-Chemical Properties and Performance of Functional Monomers Used in Contemporary Dental Adhesive Technology.The journal of adhesive dentistry · 2025Review
- A dual action approach of B-type proanthocyanidins for silencing enzymatic activity and sealing natural caries-affected dentin-resin interfaces.Journal of dentistry · 2025Article
- The Influence of Deep Margin Elevation and Immediate Dentin Sealing on the Fracture Strength of Premolars Restored With Indirect Inlays: An In Vitro Study.Clinical and experimental dental research · 2025Article
- The effect of sandblasting distances on the shear bond strength of a self-etch and total-etch adhesive system to cervical dentin in the gingival wall of Class II restorations.Dental research journal · 2025Article
- Scaffold-based Strategies for Direct Pulp Capping in Animal Models: A Systematic Review and Meta-analysis.Iranian endodontic journal · 2025Review
- Spatial polarimetric second harmonic generation evaluation of collagen in a hypophosphatasia mouse model.Biomedical optics express · 2024Article
- Biomimetic remineralization of eroded dentin by synergistic effect of calcium phosphate and plant-based biomodifying agents: AnJournal of conservative dentistry and endodontics · 2024Article
- Chios gum mastic enhance the proliferation and odontogenic differentiation of human dental pulp stem cells.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2024Article
- The influence of neutral MDP-Na salt on dentin bond performance and remineralization potential of etch-&-rinse adhesive.BMC oral health · 2024Article
- Development of a zinc chloride-based chemo-mechanical system for potential minimally invasive dental caries removal system.Journal of dental sciences · 2024Article
- In-silico simulation of nanoindentation on bone using a 2D cohesive finite element model.Journal of the mechanical behavior of biomedical materials · 2024Article
- Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The prevention and treatment of dental caries are major challenges occurring in dentistry. The foundations for modern management of this dental disease, estimated to affect 90% of adults in Western countries, rest upon the dependence of ultrafine interactions between synthetic polymeric biomaterials and nanostructured supramolecular assemblies that compose the tooth organic substrate. Research has shown, however, that this interaction imposes less than desirable long-term prospects for current resin-based dental restorations. Here we review progress in the identification of the nanostructural organization of the organic matrix of dentin, the largest component of the tooth structure, and highlight aspects relevant to understating the interaction of restorative biomaterials with the dentin substrate. We offer novel insights into the influence of the hierarchically assembled supramolecular structure of dentin collagen fibrils and their structural dependence on water molecules. Secondly, we review recent evidence for the participation of proteoglycans in composing the dentin organic network. Finally, we discuss the relation of these complexly assembled nanostructures with the protease degradative processes driving the low durability of current resin-based dental restorations. We argue in favour of the structural limitations that these complexly organized and inherently hydrated organic structures may impose on the clinical prospects of current hydrophobic and hydrolyzable dental polymers that establish ultrafine contact with the tooth substrate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.