Evidence map›Paper›PMID 22414616›Full record

ArticleProgress in neuro-psychopharmacology & biological psychiatry2012

Striatal dysfunction during failed motor inhibition in children at risk for bipolar disorder.

Christen M Deveney, Megan E Connolly, Sarah E Jenkins, Pilyoung Kim, Stephen J Fromm, Melissa A Brotman, Daniel S Pine, Ellen Leibenluft

Abstract read
In one paragraph

Article in Progress in neuro-psychopharmacology & biological psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Antidepressant-Induced Activation in Children and Adolescents: Risk, Recognition and Management.Current problems in pediatric and adolescent health care · 2018
    Review
  8. Article
  9. Article
  10. Article
  11. Neural Markers in Pediatric Bipolar Disorder and Familial Risk for Bipolar Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2017
    Article
  12. Article
  13. Neurobiology of Risk for Bipolar Disorder.Current treatment options in psychiatry · 2016
    Review
  14. Affective Processing in Pediatric Bipolar Disorder and Offspring of Bipolar Parents.Journal of child and adolescent psychopharmacology · 2015
    Article
  15. Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Christen M DeveneyEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD 20892-2670, USA. deveneycm@mail.nih.gov
Megan E Connolly
Sarah E Jenkins
Pilyoung Kim
Stephen J Fromm
Melissa A Brotman
Daniel S Pine
Ellen Leibenluft
National Institute of Mental Health · USNational Institutes of Health · US

Funding

The Pathophysiology and Treatment Of Children With Severe Mood DysregulationZIAMH002786 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEIBENLUFT, ELLEN · 2009 to 2023
$34.0M
The Phenomenology And Neurophysiology Of Juvenile Bipolar DisorderZIAMH002778 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEIBENLUFT, ELLEN · 2009 to 2017
$10.8M
The Phenomenology And Neurophysiology Of Juvenile Bipolar DisorderZ01MH002778 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEIBENLUFT, ELLEN · 2000 to 2008
$3.1M
The Characterization And Treatment Of Children With Severe Mood DysregulationZ01MH002786 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEIBENLUFT, ELLEN · 2002 to 2008
$2.8M
Intramural NIH HHS Z01 MH002778Intramural NIH HHS Z01 MH002786Intramural NIH HHS ZIA MH002778Intramural NIH HHS ZIA MH002786
6 · The paper itself

Abstract

backgroundA better understanding of the neural underpinnings of bipolar disorder (BD) can be obtained by examining brain activity in symptom-free individuals at risk for BD. This study examined the neural correlates of motor inhibition in a sample of symptom-free youths at familial risk for BD.

methods19 euthymic youths with BD, 13 asymptomatic youths with a first-degree relative with BD, and 21 healthy comparison children completed the stop signal task in a 3 T scanner.

resultsChildren at familial risk for BD exhibited increased putamen activation during unsuccessful inhibition that distinguished them from both healthy and BD children. Youths with BD exhibited reduced activation of the right nucleus accumbens during unsuccessful inhibition as compared to the other participant groups.

conclusionsStriatal activation patterns differ between youths at risk for BD and healthy comparison children during a motor inhibition task.

Indexed as

Inhibition, PsychologicalAdolescentAttentionBipolar DisorderBrain MappingChildCorpus StriatumFemaleHumansMagnetic Resonance ImagingMaleNeuropsychological TestsPsychomotor PerformanceReaction TimeRisk

Identifiers

PMID22414616
PMCPMC3389139
OpenAlexW1977148530

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.