ReviewSeminars in cell & developmental biology2012
Protein degradation and the stress response.
Review in Seminars in cell & developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 134 citations in OpenAlex.
- The single nucleotide polymorphism rs1053230 modulates kynurenine 3-monooxygenase stability and is associated with cognitive and mood phenotypes.bioRxiv : the preprint server for biology · 2026Article
- Mitochondria serve as a holdout compartment for aggregation-prone proteins hindering efficient degradation.Nature communications · 2026Article
- Pre-dauer starvation rapidly and reversibly reduces niche proliferative signaling to the Caenorhabditis elegans germ line.Development (Cambridge, England) · 2026Article
- A Novel Unorthodox Dimeric Primary Enoyl-CoA Reductase Structure.bioRxiv : the preprint server for biology · 2025Article
- Neuronal Necroptosis Drives Neuroinflammation and Cognitive Decline Independent of Neuronal Cell Death.Aging and disease · 2025Article
- Complementary genetic and epigenetic changes facilitate rapid adaptation to multiple global change stressors.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Parkinson's disease-linked Kir4.2 mutation R28C leads to loss of ion channel function.The Journal of physiology · 2025Article
- Distinct Stress Regulators in the CRL Family: Emerging Roles of F-Box Proteins: Cullin-RING Ligases and Stress-Sensing.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Mid-Pregnancy Placental Transcriptome in a Model of Placental Insufficiency with and without Novel Intervention.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Proteomics analysis of soluble secreted proteins ofFrontiers in cellular and infection microbiology · 2025Article
- Multifaceted investigations of PSMB8 provides insights into prognostic prediction and immunological target in thyroid carcinoma.PloS one · 2025Article
- Performance and tolerance of Moringa stenopetala exposed to drought stress during germination and growth.PloS one · 2025Article
- Guided tour through the small protein landscape ofmicroLife · 2025Article
- Article
- Review
- Unravelling the key steps impairing the metabolic state of Xanthomonas cells undergoing programmed cell death.International microbiology : the official journal of the Spanish Society for Microbiology · 2024Article
- p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells.Nature cell biology · 2024Article
- Identification of modules and key genes associated with breast cancer subtypes through network analysis.Scientific reports · 2024Article
- Cadmium binding by the F-box domain induces p97-mediated SCF complex disassembly to activate stress response programs.Nature communications · 2024Article
- Skin transcriptomic analysis reveals candidate genes and pathways associated with thermotolerance in hair sheep.International journal of biometeorology · 2024Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Environmental stresses are manifold and so are the responses they elicit. This is particularly true for higher eukaryotes where various tissues and cell types are differentially affected by the insult. Type and scope of the stress response can therefore differ greatly among cell types. Given the importance of the ubiquitin proteasome system (UPS) for most cellular processes, it comes as no surprise that the UPR plays a pivotal role in counteracting the effects of stressors. Here we outline contributions of the UPS to stress sensing, signaling, and response pathways. We make no claim to comprehensiveness but choose selected examples to illustrate concepts and mechanisms by which protein modification with ubiquitin and proteasomal degradation of key regulators ensures cellular integrity during stress situations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.