ArticleAlcoholism, clinical and experimental research2012
Commentary with regard to the role of alcohol and cofactors in the development of hepatocellular carcinoma.
Article in Alcoholism, clinical and experimental research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 5 citations in OpenAlex.
- Knockdown of cyclooxygenase-2 leads to growth inhibition and cell cycle arrest in hepatocellular carcinoma cells.OncoTargets and therapy · 2019Article
- Altered methylation and expression of ER-associated degradation factors in long-term alcohol and constitutive ER stress-induced murine hepatic tumors.Frontiers in genetics · 2013Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatocellular carcinoma (HCC) is a primary cancer of the liver. It is clear that chronic alcohol abuse is associated with the development of HCC, but the mechanistic role of alcohol in HCC is not well studied. The research that is presented in the Brandon-Warner and colleagues' (2012) article approaches an important outcome of chronic alcohol abuse. The most important study results that are presented in their article show convincing data that chronic alcohol consumption by male mice resulted in a robust response in the liver to a carcinogen. It was shown that female mice responded significantly less to alcohol and the carcinogen than the male animals. The overall research data covered a number of aspects of the liver disease associated with chronic alcohol consumption and the presence of a carcinogen that will support a great deal of further research to develop mechanistic data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.