ArticleScientific reports2012
Expression of GluK1c underlies the developmental switch in presynaptic kainate receptor function.
Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- GluK1 kainate receptors in parvalbumin interneurons modulate cortico-hippocampal network dynamics during social behavior.Translational psychiatry · 2026Article
- GluK1 kainate receptors are necessary for functional maturation of parvalbumin interneurons regulating amygdala circuit function.Molecular psychiatry · 2024Article
- A Pathogenic Missense Mutation in Kainate Receptors Elevates Dendritic Excitability and Synaptic Integration through Dysregulation of SK Channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Of the Mechanisms of Paroxysmal Depolarization Shifts: Generation and Maintenance of Bicuculline-Induced Paroxysmal Activity in Rat Hippocampal Cell Cultures.International journal of molecular sciences · 2023Article
- Interneuronal GluK1 kainate receptors control maturation of GABAergic transmission and network synchrony in the hippocampus.Molecular brain · 2023Article
- Delving into the significance of the His289Tyr single-nucleotide polymorphism in the glutamate ionotropic receptor kainate-1 (Frontiers in molecular neuroscience · 2023Article
- Downregulation of kainate receptors regulating GABAergic transmission in amygdala after early life stress is associated with anxiety-like behavior in rodents.Translational psychiatry · 2021Article
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data.Cellular and molecular life sciences : CMLS · 2021Article
- A kainate receptor-selective RNA aptamer.The Journal of biological chemistry · 2020Article
- Kainate receptors regulate development of glutamatergic synaptic circuitry in the rodent amygdala.eLife · 2020Article
- The Kainate Receptor Subunit GluK2 Interacts With KCC2 to Promote Maturation of Dendritic Spines.Frontiers in cellular neuroscience · 2020Article
- NETO1 Regulates Postsynaptic Kainate Receptors in CA3 Interneurons During Circuit Maturation.Molecular neurobiology · 2019Article
- The Role of Kainate Receptors in the Pathophysiology of Hypoxia-Induced Seizures in the Neonatal Mouse.Scientific reports · 2018Article
- A kainate receptor subunit promotes the recycling of the neuron-specific KThe Journal of biological chemistry · 2017Article
- Antioxidative Effects of Natural Products on Diabetic Cardiomyopathy.Journal of diabetes research · 2017Review
- HMGB4 is expressed by neuronal cells and affects the expression of genes involved in neural differentiation.Scientific reports · 2016Article
- Axonal Kainate Receptors Modulate the Strength of Efferent Connectivity by Regulating Presynaptic Differentiation.Frontiers in cellular neuroscience · 2016Article
- The auxiliary subunits Neto1 and Neto2 have distinct, subunit-dependent effects at recombinant GluK1- and GluK2-containing kainate receptors.Neuropharmacology · 2015Article
- Activity-dependent upregulation of presynaptic kainate receptors at immature CA3-CA1 synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kainate-type glutamate receptors (KARs) regulate synaptic transmission and neuronal excitability via multiple mechanisms, depending on their subunit composition. Presynaptic KARs tonically depress glutamatergic transmission during restricted period of synapse development; however, the molecular basis behind this effect is unknown. Here, we show that the developmental and cell-type specific expression pattern of a KAR subunit splice variant, GluK1c, corresponds to the immature-type KAR activity in the hippocampus. GluK1c localizes to dendritic contact sites at distal axons, the distal targeting being promoted by heteromerization with the subunit GluK4. Presynaptic expression of GluK1c strongly suppresses glutamatergic transmission in cell-pairs in vitro and mimics the immature-type KAR activity at CA3-CA1 synapses in vivo, at a developmental stage when the endogenous expression is already downregulated. These data support a central role for GluK1c in mediating tonic inhibition of glutamate release and the consequent effects on excitability and activity-dependent fine-tuning of the developing hippocampal circuitry.
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