ArticlePloS one2012
Persistent humoral immune responses in the CNS limit recovery of reactivated murine cytomegalovirus.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- B cells in non-lymphoid tissues.Nature reviews. Immunology · 2025Review
- bTInternational journal of molecular sciences · 2025Article
- Plasma cells in and around the central nervous system.Frontiers in immunology · 2025Review
- Immune responses drive chorioretinitis and retinal pathology after neonatal CMV infection.Science advances · 2024Article
- Immune surveillance of cytomegalovirus in tissues.Cellular & molecular immunology · 2024Review
- Murine Models of Central Nervous System Disease following Congenital Human Cytomegalovirus Infections.Pathogens (Basel, Switzerland) · 2021Review
- Adaptive and Innate Immune Cells in Fetal Human Cytomegalovirus-Infected Brains.Microorganisms · 2020Article
- Glial Cell Expression of PD-L1.International journal of molecular sciences · 2019Review
- The Role of BAFF System Molecules in Host Response to Pathogens.Clinical microbiology reviews · 2017Review
- Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality.PLoS pathogens · 2017Article
- Modulation of Microglial Cell Fcγ Receptor Expression Following Viral Brain Infection.Scientific reports · 2017Article
- Glial cell activation, recruitment, and survival of B-lineage cells following MCMV brain infection.Journal of neuroinflammation · 2016Article
- Chronic reactive gliosis following regulatory T cell depletion during acute MCMV encephalitis.Glia · 2015Article
- Immunobiology of congenital cytomegalovirus infection of the central nervous system—the murine cytomegalovirus model.Cellular & molecular immunology · 2015Review
- Tregs Modulate Lymphocyte Proliferation, Activation, and Resident-Memory T-Cell Accumulation within the Brain during MCMV Infection.PloS one · 2015Article
- Infiltrating regulatory B cells control neuroinflammation following viral brain infection.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Article
- Activated CD8+ T lymphocytes inhibit neural stem/progenitor cell proliferation: role of interferon-gamma.PloS one · 2014Article
- Immune responses to congenital cytomegalovirus infection.Microbes and infectionReview
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundExperimental infection of the mouse brain with murine CMV (MCMV) elicits neuroimmune responses that terminate acute infection while simultaneously preventing extensive bystander damage. Previous studies have determined that CD8(+) T lymphocytes are required to restrict acute, productive MCMV infection within the central nervous system (CNS). In this study, we investigated the contribution of humoral immune responses in control of MCMV brain infection. METHODOLOGY/PRINCIPAL
findingsUtilizing our MCMV brain infection model, we investigated B-lymphocyte-lineage cells and assessed their role in controlling the recovery of reactivated virus from latently infected brain tissue. Brain infiltrating leukocytes were first phenotyped using markers indicative of B-lymphocytes and plasma cells. Results obtained during these studies showed a steady increase in the recruitment of B-lymphocyte-lineage cells into the brain throughout the time-course of viral infection. Further, MCMV-specific antibody secreting cells (ASC) were detected within the infiltrating leukocyte population using an ELISPOT assay. Immunohistochemical studies of brain sections revealed co-localization of CD138(+) cells with either IgG or IgM. Additional immunohistochemical staining for MCMV early antigen 1 (E1, m112-113), a reported marker of viral latency in neurons, confirmed its expression in the brain during latent infection. Finally, using B-cell deficient (Jh(-/-)) mice we demonstrated that B-lymphocytes control recovery of reactivated virus from latently-infected brain tissue. A significantly higher rate of reactivated virus was recovered from the brains of Jh(-/-) mice when compared to Wt animals.
conclusionTaken together, these results demonstrate that MCMV infection triggers accumulation and persistence of B-lymphocyte-lineage cells within the brain, which produce antibodies and play a significant role in controlling reactivated virus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.