ArticlePloS one2012
Detailed mitochondrial phenotyping by high resolution metabolomics.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed.
- Serum metabolomics of slow vs. rapid motor progression Parkinson's disease: a pilot study.PloS one · 2013Trial
- Trial
- Mitochondrial Metabolomics in Cancer: Mass Spectrometry-Based Approaches for Metabolic Rewiring Analysis and Therapeutic Discovery.Metabolites · 2025Review
- Technologies for Decoding Cancer Metabolism with Spatial Resolution.Cold Spring Harbor perspectives in medicine · 2025Review
- ALTERATIONS IN HISTIDINE METABOLISM IS A FEATURE OF EARLY AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE (ADPKD).Transactions of the American Clinical and Climatological Association · 2024Article
- Mitochondrial Metabolomics of Sym1-Depleted Yeast Cells Revealed Them to Be Lysine Auxotroph.Cells · 2023Article
- Sub-Cellular Metabolomics Contributes Mitochondria-Specific Metabolic Insights to a Mouse Model of Leigh Syndrome.Metabolites · 2021Article
- Trisomy 21 results in modest impacts on mitochondrial function and central carbon metabolism.Free radical biology & medicine · 2021Article
- Transporters at the Interface between Cytosolic and Mitochondrial Amino Acid Metabolism.Metabolites · 2021Review
- Isolation and Metabolic Assessment of Cancer Cell Mitochondria.ACS omega · 2020Article
- Metabolic Modelling as a Framework for Metabolomics Data Integration and Analysis.Metabolites · 2020Review
- Novel mitochondrial and cytosolic purification pipeline for compartment-specific metabolomics in mammalian disease model tissues.Metabolomics : Official journal of the Metabolomic Society · 2020Article
- Omics Integration for Mitochondria Systems Biology.Antioxidants & redox signaling · 2020Review
- Integrative omics approaches provide biological and clinical insights: examples from mitochondrial diseases.The Journal of clinical investigation · 2020Review
- Should we consider subcellular compartmentalization of metabolites, and if so, how do we measure them?Current opinion in clinical nutrition and metabolic care · 2019Review
- MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- A biplot correlation range for group-wise metabolite selection in mass spectrometry.BioData mining · 2019Article
- Stereochemical and structural effects of (2R,6R)-hydroxynorketamine on the mitochondrial metabolome in PC-12 cells.Biochimica et biophysica acta. General subjects · 2018Article
- Metabolic profiling of isolated mitochondria and cytoplasm reveals compartment-specific metabolic responses.Metabolomics : Official journal of the Metabolomic Society · 2018Article
- Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites.Nature protocols · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Mitochondrial phenotype is complex and difficult to define at the level of individual cell types. Newer metabolic profiling methods provide information on dozens of metabolic pathways from a relatively small sample. This pilot study used "top-down" metabolic profiling to determine the spectrum of metabolites present in liver mitochondria. High resolution mass spectral analyses and multivariate statistical tests provided global metabolic information about mitochondria and showed that liver mitochondria possess a significant phenotype based on gender and genotype. The data also show that mitochondria contain a large number of unidentified chemicals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.