ReviewJournal of clinical oncology : official journal of the American Society of Clinical Oncology2012
Evidence-based treatment of delirium in patients with cancer.
Review in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03360474 (The Implementation of a Delirium Screening and Intervention Protocol for Critically Ill Patients), which is not on this map. Cited by 55 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Implementation of a Delirium Screening and Intervention Protocol for Critically Ill Patients
Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 182 citations in OpenAlex.
- Cholinesterase inhibitors for the treatment of delirium in non-ICU settings.The Cochrane database of systematic reviews · 2018Pooled it
- Antipsychotic-induced akathisia in delirium: A systematic review.Palliative & supportive care · 2016Pooled it
- [Pharmacological treatment of delirium in palliative care patients. A systematic literature review].Schmerz (Berlin, Germany) · 2013Pooled it
- Melatonin to prevent delirium in patients with advanced cancer: a double blind, parallel, randomized, controlled, feasibility trial.BMC palliative care · 2020Trial
- Clinical Pharmacokinetics of a Lipid-Based Formulation of Risperidone, VAL401: Analysis of a Single Dose in an Open-Label Trial of Late-Stage Cancer Patients.European journal of drug metabolism and pharmacokinetics · 2019Trial
- Haloperidol prophylaxis for preventing aggravation of postoperative delirium in elderly patients: a randomized, open-label prospective trial.Surgery today · 2017Trial
- Delirium in the oncology intensive care unit: Risk, recognition, and recovery strategies.World journal of critical care medicine · 2026Review
- Prevalence, associated factors, and prognostic impact of delirium in advanced cancer patients in acute palliative care units: a prospective observational study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Large language models vs. conventional search in identifying delirium guidelines for a scoping review.BMC medical research methodology · 2026Article
- Neurological Comorbidity Burden, Outcomes, and Disparities in Head and Neck Cancer During COVID-19.Reports (MDPI) · 2026Article
- Risk factors associated with cancer and metabolic encephalopathy in Alzheimer's disease patients.Frontiers in aging neuroscience · 2026Article
- Delirium associated with trifluridine/tipiracil in an elderly patient with metastatic colorectal cancer: A case report.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Intravenous haloperidol or chlorpromazine-which is more effective to improve agitation and communication in agitated delirium at the end of life?The oncologist · 2025Article
- Reflecting on Cancer Pain as Constant Acute Pain, not Chronic Pain. 'Known Knowns, Known Unknowns, Unknown Unknowns'.Current oncology reports · 2025Review
- Drugs, delirium, and ethics at the end of life.Journal of the American Geriatrics Society · 2024Article
- A qualitative feasibility and acceptability study of an acceptance and commitment-based bibliotherapy intervention for people with cancer.Journal of health psychology · 2024Article
- Impact of mental health on burden of illness, septicemia and mortality among patients hospitalized for cancer.PLOS mental health · 2024Article
- Review
- Delirium as a Risk Factor for Mortality in Critically Ill Patients With Cancer.JCO oncology practice · 2023Article
- Preventing and treating delirium in clinical settings for older adults.Therapeutic advances in psychopharmacology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Delirium is the most common neuropsychiatric complication seen in patients with cancer, and it is associated with significant morbidity and mortality. Increased health care costs, prolonged hospital stays, and long-term cognitive decline are other well-recognized adverse outcomes of delirium. Improved recognition of delirium and early treatment are important in diminishing such morbidity. There has been an increasing number of studies published in the literature over the last 10 years regarding delirium treatment as well as prevention. Antipsychotics, cholinesterase inhibitors, and alpha-2 agonists are the three groups of medications that have been studied in randomized controlled trials in different patient populations. In patients with cancer, the evidence is most clearly supportive of short-term, low-dose use of antipsychotics for controlling the symptoms of delirium, with close monitoring for possible adverse effects, especially in older patients with multiple medical comorbidities. Nonpharmacologic interventions also appear to have a beneficial role in the treatment of patients with cancer who have or are at risk for delirium. This article presents evidence-based recommendations based on the results of pharmacologic and nonpharmacologic studies of the treatment and prevention of delirium.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.