Trial reportClinical infectious diseases : an official publication of the Infectious Diseases Society of America2012
Predicting the clinical outcome of severe falciparum malaria in african children: findings from a large randomized trial.
Trial report in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
117 citing papers in PubMed, 5 syntheses or guidelines pooled it, 188 citations in OpenAlex.
- The prognostic and diagnostic value of intraleukocytic malaria pigment in patients with severe falciparum malaria.Nature communications · 2022Pooled it
- Predictors of disease severity in children presenting from the community with febrile illnesses: a systematic review of prognostic studies.BMJ global health · 2021Pooled it
- High value of rapid diagnostic tests to diagnose malaria within children: A systematic review and meta-analysis.Journal of global health · 2020Pooled it
- Prognostic models for the clinical management of malaria and its complications: a systematic review.BMJ open · 2019Pooled it
- Clinical and laboratory predictors of death in African children with features of severe malaria: a systematic review and meta-analysis.BMC medicine · 2017Pooled it
- Trial
- Prostration and the prognosis of death in African children with severe malaria.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023Trial
- Identifying prognostic factors of severe metabolic acidosis and uraemia in African children with severe falciparum malaria: a secondary analysis of a randomized trial.Malaria journal · 2021Trial
- Acetaminophen as a Renoprotective Adjunctive Treatment in Patients With Severe and Moderately Severe Falciparum Malaria: A Randomized, Controlled, Open-Label Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Trial
- Immunomodulation Therapy to Treat Severe Malaria With Multiple Organ Failure.Critical care explorations · 2026Article
- Population Pharmacokinetics and Pharmacodynamics of Paracetamol in Malaysian Patients With Plasmodium knowlesi Malaria.CPT: pharmacometrics & systems pharmacology · 2026Article
- Clinical profiles and predictors of intensive care unit transfer among children hospitalized with severe Plasmodium falciparum malaria in a tertiary care hospital in Libreville, Gabon: a retrospective study.BMC infectious diseases · 2026Article
- Malarial pneumonopathy in Malawian children with cerebral malaria.Malaria journal · 2026Observational
- Risk factors for malaria-related mortality among children under five at Mbale Regional Referral Hospital, Uganda, 2020-2024: A case-control study.PLOS global public health · 2026Article
- Characteristics and mortality factors of severe malaria in children and teenager aged from 5 to 15 years in Thiès region, Senegal.IJID regions · 2025Article
- Identification of acute kidney injury in African children with severe malaria: a multinational individual participant data meta-analysis.Research square · 2025Article
- Emerging trends and new developments in global research on artemisinin and its derivatives.Heliyon · 2025Article
- Prevalence and factors associated with cerebral malaria among children aged 6 to 59 months with severe malaria in Western Uganda: a hospital-based cross-sectional study.BMC pediatrics · 2024Article
- The gut microbiome is associated with susceptibility to febrile malaria in Malian children.Nature communications · 2024Article
- Defining the next generation of severe malaria treatment: a target product profile.Malaria journal · 2024Review
57 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors at 9 institutions in 9 countries.
Funding
Abstract
backgroundData from the largest randomized, controlled trial for the treatment of children hospitalized with severe malaria were used to identify such predictors of a poor outcome from severe malaria.
methodsAfrican children (<15 years) with severe malaria participated in a randomized comparison of parenteral artesunate and parenteral quinine in 9 African countries. Detailed clinical assessment was performed on admission. Parasite densities were assessed in a reference laboratory. Predictors of death were examined using a multivariate logistic regression model.
resultsTwenty indicators of disease severity were assessed, out of which 5 (base deficit, impaired consciousness, convulsions, elevated blood urea, and underlying chronic illness) were associated independently with death. Tachypnea, respiratory distress, deep breathing, shock, prostration, low pH, hyperparasitemia, severe anemia, and jaundice were statistically significant indicators of death in the univariate analysis but not in the multivariate model. Age, glucose levels, axillary temperature, parasite density, heart rate, blood pressure, and blackwater fever were not related to death in univariate models.
conclusionsAcidosis, cerebral involvement, renal impairment, and chronic illness are key independent predictors for a poor outcome in African children with severe malaria. Mortality is markedly increased in cerebral malaria combined with acidosis. Clinical Trial Registration. ISRCTN50258054.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.