Trial reportPediatrics2012
Hospital variation in nitric oxide use for premature infants.
Trial report in Pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Increase in the use of inhaled nitric oxide in neonatal intensive care units in England: a retrospective population study.BMJ paediatrics open · 2021Trial
- Impact of the neonatal intensive critical ultrasound workflow for managing neonatal acute pulmonary hypertension.Frontiers in pediatrics · 2026Article
- Pulmonary vasodilator use in very preterm infants in United States children's hospitals.Journal of perinatology : official journal of the California Perinatal Association · 2025Observational
- Sildenafil as Bridge Therapy for Inhaled Nitric Oxide in Preterm Neonates.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2024Article
- The early use of inhaled nitric oxide in premature infants requiring respiratory support.Annals of medicine · 2023Review
- Implementation of an Inhaled Nitric Oxide Weaning Protocol and Stewardship in a Level 4 NICU to Decrease Inappropriate Use.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022Article
- Cost of clinician-driven tests and treatments in very low birth weight and/or very preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Hospital Variation in Child Protection Reports of Substance Exposed Infants.The Journal of pediatrics · 2019Article
- Early inhaled nitric oxide in preterm infants <34 weeks with evolving bronchopulmonary dysplasia.Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- Inhaled nitric oxide use in preterm infants in California neonatal intensive care units.Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- Variation in treatment of neonatal abstinence syndrome in US children's hospitals, 2004-2011.Journal of perinatology : official journal of the California Perinatal Association · 2014Article
- Inhaled nitric oxide usage in preterm infants in the NICHD Neonatal Research Network: inter-site variation and propensity evaluation.Journal of perinatology : official journal of the California Perinatal Association · 2014Article
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo describe inter-center hospital variation in inhaled nitric oxide (iNO) administration to infants born prior to 34 weeks' gestation at US children's hospitals.
methodsThis was a retrospective cohort study using the Pediatric Health Information System to determine the frequency, age at first administration, and length of iNO use among 22 699 consecutive first admissions of unique <34 weeks' gestation infants admitted to 37 children's hospitals from January 1, 2007, through December 31, 2010.
resultsA total of 1644 (7.2%) infants received iNO during their hospitalization, with substantial variation in iNO use between hospitals (range across hospitals: 0.5%-26.2%; P < .001). The age at which iNO was started varied by hospital (mean: 20.0 days; range: 6.0-65.1 days, P < .001), as did the duration of therapy (mean: 13.1 days; range: 1.0-31.1 days; P < .001). Preterm infants who received iNO were less likely to survive (36.3% mortality vs 8.3%; odds ratio: 6.27; P < .001). The association between the use of iNO and mortality persists in propensity score-adjusted analyses controlling for demographic factors and diagnoses associated with the use of iNO (odds ratio: 3.79; P < .0001).
conclusionsiNO practice patterns in preterm infants varied widely among institutions. Infants who received iNO were less likely to survive, suggesting that iNO is used in infants already at high risk of death. Adherence to National Institutes of Health consensus guidelines may decrease variation in iNO use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.