ArticleThe Journal of biological chemistry2012
Inhibition of colony-spreading activity of Staphylococcus aureus by secretion of δ-hemolysin.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Genomic characterization of Staphylococcus epidermidis Se252 isolated from the rhizosphere of a Brazilian endemic plant.BMC genomics · 2025Article
- Exploring the incidence potential of phenol-soluble modulins among methicillin-resistant Staphylococcus aureus in Lahore, Pakistan.BMC infectious diseases · 2025Article
- Prevalence of virulence- and antibiotic resistance-associated genotypes and phenotypes inFrontiers in cellular and infection microbiology · 2024Article
- Involvement of Heme in Colony Spreading ofFrontiers in microbiology · 2020Article
- From Staphylococcus aureus gene regulation to its pattern formation.Journal of mathematical biology · 2019Article
- Antimicrobial Activity and Mechanism of Action ofFrontiers in microbiology · 2019Article
- Defining motility in the Staphylococci.Cellular and molecular life sciences : CMLS · 2017Review
- Modulation of Staphylococcus aureus spreading by water.Scientific reports · 2016Article
- Exploration of Modulated Genetic Circuits Governing Virulence Determinants in Staphylococcus aureus.Indian journal of microbiology · 2016Review
- PSM-Mec-A Virulence Determinant that Connects Transcriptional Regulation, Virulence, and Antibiotic Resistance in Staphylococci.Frontiers in microbiology · 2016Review
- Cell-Surface Phenol Soluble Modulins Regulate Staphylococcus aureus Colony Spreading.PloS one · 2016Article
- Staphylococcus aureus forms spreading dendrites that have characteristics of active motility.Scientific reports · 2015Article
- Functional characteristics of the Staphylococcus aureus δ-toxin allelic variant G10S.Scientific reports · 2015Article
- Fold modulating function: bacterial toxins to functional amyloids.Frontiers in microbiology · 2014Review
- Identification of Staphylococcus aureus colony-spreading stimulatory factors from mammalian serum.PloS one · 2014Article
- Silkworm apolipophorin protein inhibits hemolysin gene expression of Staphylococcus aureus via binding to cell surface lipoteichoic acids.The Journal of biological chemistry · 2013Article
- Mobile genetic element SCCmec-encoded psm-mec RNA suppresses translation of agrA and attenuates MRSA virulence.PLoS pathogens · 2013Article
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Authors and funding
3 authors.
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Abstract
Staphylococcus aureus spreads on the surface of soft agar, a phenomenon we termed "colony spreading." Here, we found that S. aureus culture supernatant inhibited colony spreading. We purified δ-hemolysin (Hld, δ-toxin), a major protein secreted from S. aureus, as a compound that inhibits colony spreading. The culture supernatants of hld-disrupted mutants had 30-fold lower colony-spreading inhibitory activity than those of the parent strain. Furthermore, hld-disrupted mutants had higher colony-spreading ability than the parent strain. These results suggest that S. aureus negatively regulates colony spreading by secreting δ-hemolysin.
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