Trial reportLipids2012
Oral supplementation with dihomo-γ-linolenic acid (DGLA)-enriched oil increases serum DGLA content in healthy adults.
Trial report in Lipids, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02211417 (A Randomised, Double-Blind, Placebo-Controlled, Phase II Study to Assess the Efficacy and Safety of Orally Administered DS107G to Patients With Moderate to Severe Atopic Dermatitis), which is not on this map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomised, Double-Blind, Placebo-Controlled, Phase II Study to Assess the Efficacy and Safety of Orally Administered DS107G to Patients With Moderate to Severe Atopic Dermatitis
Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Trial
- The physiological and pathological properties of Mead acid, an endogenous multifunctional n-9 polyunsaturated fatty acid.Lipids in health and disease · 2023Review
- Dihomo-International journal of molecular sciences · 2023Review
- Dihomo-γ-linolenic acid inhibits several key cellular processes associated with atherosclerosis.Biochimica et biophysica acta. Molecular basis of disease · 2019Article
- Serum fatty acids and progression from dengue fever to dengue haemorrhagic fever/dengue shock syndrome.The British journal of nutrition · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dihomo-γ-linolenic acid (DGLA) is one of the polyunsaturated fatty acids, and is expected to show anti-allergic activity. We examined the effects of supplementation with DGLA-enriched oil (450 mg as free DGLA) for 4 weeks in healthy adults in a randomized controlled study. The DGLA composition in the total fatty acids of serum phospholipids increased from 2.0 to 3.4%, and returned to the initial level after a 4-week washout. No side effects or changes in blood biochemical parameters were observed. These results indicate that serum DGLA content can be safely increased by supplementation with 450 mg DGLA under these conditions.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.