ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2013
Spatial patterns of the tau pathology in progressive supranuclear palsy.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Primary age-related tauopathy.Acta neuropathologica · 2025Review
- Selective cellular and regional vulnerability in frontotemporal lobar degeneration: a scoping review.Free neuropathology · 2025Review
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- Identification and analysis of a selective DYRK1A inhibitor.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022Article
- Article
- Does the Anti-Tau Strategy in Progressive Supranuclear Palsy Need to Be Reconsidered? Yes.Movement disorders clinical practice · 2021Article
- Tau Pathology in Parkinson's Disease.Frontiers in neurology · 2018Review
- Protein astrogliopathies in human neurodegenerative diseases and aging.Brain pathology (Zurich, Switzerland) · 2017Review
- Imaging tau pathology in Parkinsonisms.NPJ Parkinson's disease · 2017Review
- Imaging pathological tau in atypical parkinsonian disorders.Current opinion in neurology · 2015Review
- Neuroimaging evidence of gray and white matter damage and clinical correlates in progressive supranuclear palsy.Journal of neurology · 2015Article
- The neurogenetics of atypical parkinsonian disorders.Seminars in neurology · 2014Review
- Cerebral magnetic resonance elastography in supranuclear palsy and idiopathic Parkinson's disease.NeuroImage. Clinical · 2013Article
- Saccades in progressive supranuclear palsy - maladapted, irregular, curved, and slow.Movement disorders clinical practiceArticle
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Progressive supranuclear palsy (PSP) is characterized neuropathologically by neuronal loss, gliosis, and the presence of tau-immunoreactive neuronal and glial cell inclusions affecting subcortical and some cortical regions. The objectives of this study were to determine (1) the spatial patterns of the tau-immunoreactive pathology, viz., neurofibrillary tangles (NFT), oligodendroglial inclusions (GI), tufted astrocytes (TA), and Alzheimer's disease-type neuritic plaques (NP) in PSP and (2) to investigate the spatial correlations between the histological features. Post-mortem material of cortical and subcortical regions of eight PSP cases was studied. Spatial pattern analysis was applied to the NFT, GI, TA, NP, abnormally enlarged neurons (EN), surviving neurons, and glial cells. NFT, GI, and TA were distributed either at random or in regularly distributed clusters. The EN and NP were mainly randomly distributed. Clustering of NFT and EN was more frequent in the cortex and subcortical regions, respectively. Variations in NFT density were not spatially correlated with the densities of either GI or TA, but were positively correlated with the densities of EN and surviving neurons in some regions. (1) NFT were the most widespread tau-immunoreactive pathology in PSP being distributed randomly in subcortical regions and in regular clusters in cortical regions, (2) GI and TA were more localized and exhibited a regular pattern of clustering in subcortical regions, and (3) neuronal and glial cell pathologies were not spatially correlated.
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