ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2012
Immunophenotypic characterization of enteric neural crest cells in the developing avian colorectum.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 33 citations in OpenAlex.
- Three-dimensional-mapping of smooth muscle morphogenesis in the vertebrate gastrointestinal tract.Scientific reports · 2025Article
- Intramuscular enteric glia persist in Hirschsprung disease and undergo neurogenesis in response to GDNF-NCAM1 signaling.Scientific reports · 2025Article
- Cecal growth factors promote enteric neurosphere formation and hindgut colonization in the avian model.Frontiers in cell and developmental biology · 2025Article
- Agrin Inhibition in Enteric Neural Stem Cells Enhances Their Migration Following Colonic Transplantation.Stem cells translational medicine · 2024Article
- Essential Role of BMP4 Signaling in the Avian Ceca in Colorectal Enteric Nervous System Development.International journal of molecular sciences · 2023Article
- CXCR4 and CXCL12 signaling regulates the development of extrinsic innervation to the colorectum.Development (Cambridge, England) · 2023Article
- A distinct transcriptome characterizes neural crest-derived cells at the migratory wavefront during enteric nervous system development.Development (Cambridge, England) · 2023Article
- RET overactivation leads to concurrent Hirschsprung disease and intestinal ganglioneuromas.Development (Cambridge, England) · 2020Article
- Large intestine embryogenesis: Molecular pathways and related disorders (Review).International journal of molecular medicine · 2020Review
- Transplanted enteric neural stem cells integrate within the developing chick spinal cord: implications for spinal cord repair.Journal of anatomy · 2018Article
- Collagen 18 and agrin are secreted by neural crest cells to remodel their microenvironment and regulate their migration during enteric nervous system development.Development (Cambridge, England) · 2018Article
- Enteric nervous system development: A crest cell's journey from neural tube to colon.Seminars in cell & developmental biology · 2017Review
- Intestinal smooth muscle is required for patterning the enteric nervous system.Journal of anatomy · 2017Article
- L1CAM in the Early Enteric and Urogenital System.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2017Article
- Cell-cycle-dependent TGFβ-BMP antagonism regulates neural tube closure by modulating tight junctions.Journal of cell science · 2017Article
- Molecular fingerprinting delineates progenitor populations in the developing zebrafish enteric nervous system.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Article
- White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies.Developmental biology · 2016Review
- Ibuprofen slows migration and inhibits bowel colonization by enteric nervous system precursors in zebrafish, chick and mouse.Developmental biology · 2016Article
- Sonic hedgehog controls enteric nervous system development by patterning the extracellular matrix.Development (Cambridge, England) · 2016Article
- A chicken model of pharmacologically-induced Hirschsprung disease reveals an unexpected role of glucocorticoids in enteric aganglionosis.Biology open · 2015Article
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
Abstract
backgroundThe enteric nervous system (ENS) develops from neural crest-derived cells that migrate along the intestine to form two plexuses of neurons and glia. While the major features of ENS development are conserved across species, minor differences exist, especially in the colorectum. Given the embryologic and disease-related importance of the distal ENS, the aim of this study was to characterize the migration and differentiation of enteric neural crest-derived cells (ENCCs) in the colorectum of avian embryos.
resultsUsing normal chick embryos and vagal neural tube transplants from green fluorescent protein (GFP) -transgenic chick embryos, we find ENCCs entering the colon at embryonic day (E) 6.5, with colonization complete by E8. Undifferentiated ENCCs at the wavefront express HNK-1, N-cadherin, Sox10, p75, and L1CAM. By E7, differentiation begins in the proximal colon, with L1CAM and Sox10 becoming restricted to neuronal and glial lineages, respectively. By E8, multiple markers of differentiation are expressed along the entire colorectum.
conclusionsOur results establish the pattern of ENCC migration and differentiation in the chick colorectum, demonstrate the conservation of marker expression across species, highlight a range of markers, including neuronal cell adhesion molecules, which label cells at the wavefront, and provide a framework for future studies in avian ENS development.
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