ArticleObesity surgery2012
Association of ghrelin receptor promoter polymorphisms with weight loss following Roux-en-Y gastric bypass surgery.
Article in Obesity surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- The Influence of Single Nucleotide Polymorphisms On Body Weight Trajectory After Bariatric Surgery: A Systematic Review.Current obesity reports · 2023Pooled it
- A Systematic Review of Genetic Correlates of Weight Loss After Bariatric Surgery.Obesity surgery · 2021Pooled it
- Genetic variability in the leptin-melanocortin pathway and its role in weight loss.Molecular metabolism · 2026Review
- The Phantom Satiation Hypothesis of Bariatric Surgery.Frontiers in neuroscience · 2021Article
- Genetic background influences weight-loss trajectories on the mid-term after bariatric surgery.International journal of obesity (2005) · 2019Article
- Polygenic risk score for predicting weight loss after bariatric surgery.JCI insight · 2018Article
- Effect of vertical sleeve gastrectomy on alcohol consumption and preferences in dietary obese rats and mice: A plausible role for altered ghrelin signaling.Brain research bulletin · 2018Article
- Heterozygosity for the rs696217 SNP in the Preproghrelin Gene Predicts Weight Loss After Bariatric Surgery in Severely Obese Individuals.Obesity surgery · 2017Article
- Ghrelin is independently associated with anti-mullerian hormone levels in obese but not non-obese women with polycystic ovary syndrome.Endocrine · 2017Article
- Altered ghrelin secretion in mice in response to diet-induced obesity and Roux-en-Y gastric bypass.Molecular metabolism · 2014Article
- Gene expression profiling in subcutaneous, visceral and epigastric adipose tissues of patients with extreme obesity.International journal of obesity (2005) · 2014Article
- Clinical factors associated with weight loss outcomes after Roux-en-Y gastric bypass surgery.Obesity (Silver Spring, Md.) · 2014Observational
- Bariatric surgery in the era of personalized medicine.Gastroenterology · 2013Article
- Obesity: Weight loss after Roux-en-Y gastric bypass is associated with SNPs in ghrelin receptor gene.Nature reviews. Gastroenterology & hepatology · 2012Article
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7 authors at 2 institutions in 1 country.
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Abstract
backgroundGhrelin plays a role in appetite and has been hypothesized to play a role in the mechanism of Roux-en-Y gastric bypass (RYGB) surgery. Single nucleotide polymorphisms (SNPs) in the promoter region of its receptor gene (growth hormone secretagogue receptor type 1a--GHSR) have also been associated with weight loss outcomes following long-term dietary intervention in adults with impaired glucose tolerance. Our objectives were to evaluate changes in serum ghrelin levels and determine the effect of GHSR promoter polymorphisms on post-RYGB surgery weight loss.
methodsPreoperative and 6-month postoperative serum ghrelin levels were measured in 37 patients with extreme obesity undergoing RYGB surgery. Total ghrelin was also measured in liver tissue collected intraoperatively. Association analysis between genotypes for SNPs rs9819506 and rs490683 in the promoter region of the GHSR gene and weight loss outcomes in the 30 months following surgery was performed in over 650 RYGB patients.
resultsSerum ghrelin levels increased after RYGB surgery. Weight loss trajectories were significantly different using an additive model for both ghrelin SNPs, with patients homozygous for the rs490683 CC genotype exhibiting the most weight loss. Weight loss trajectories were also different using a dominant model. The rs490683 risk allele demonstrated decreased promoter activity in vitro.
conclusionsThe role of increased ghrelin levels in weight loss outcomes following RYGB surgery may be influenced by variation in the GHSR gene.
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