ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2012
Neural crest cells pattern the surface cephalic ectoderm during FEZ formation.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Downstream branches of receptor tyrosine kinase signaling act interdependently to shape the face.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Article
- PBX1 and PBX3 transcription factors regulate SHH expression in the Frontonasal Ectodermal Zone through complementary mechanisms.PLoS genetics · 2025Article
- Epithelial-mesenchymal crosstalk: the scriptwriter of craniofacial morphogenesis.Frontiers in cell and developmental biology · 2024Review
- Evolutionary mechanisms modulating the mammalian skull development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Shared heritability of human face and brain shape.Nature genetics · 2021Article
- FGF signalling plays similar roles in development and regeneration of the skeleton in the brittle star Amphiura filiformis.Development (Cambridge, England) · 2021Article
- Creating Avian Forebrain Chimeras to assess Facial Development.Journal of visualized experiments : JoVE · 2021Article
- Article
- Evolutionary and ontogenetic changes of the anatomical organization and modularity in the skull of archosaurs.Scientific reports · 2020Article
- miR-199 family contributes to regulation of sonic hedgehog expression during craniofacial development.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Article
- Evolvability of the vertebrate craniofacial skeleton.Seminars in cell & developmental biology · 2019Review
- Molecular and cellular mechanisms underlying the evolution of form and function in the amniote jaw.EvoDevo · 2019Review
- Neural crest and the origin of species-specific pattern.Genesis (New York, N.Y. : 2000) · 2018Review
- A tissue-specific role for intraflagellar transport genes during craniofacial development.PloS one · 2017Article
- Craniofacial Ciliopathies Reveal Specific Requirements for GLI Proteins during Development of the Facial Midline.PLoS genetics · 2016Article
- Neural crest-mediated bone resorption is a determinant of species-specific jaw length.Developmental biology · 2015Article
- Signals from the brain induce variation in avian facial shape.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- A dynamic Shh expression pattern, regulated by SHH and BMP signaling, coordinates fusion of primordia in the amniote face.Development (Cambridge, England) · 2015Article
- Co-ordinated brain and craniofacial development depend upon Patched1/XIAP regulation of cell survival.Human molecular genetics · 2015Article
- Facial Morphogenesis: Physical and Molecular Interactions Between the Brain and the Face.Current topics in developmental biology · 2015Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMultiple fibroblast growth factor (Fgf) ligands are expressed in the forebrain and facial ectoderm, and vascular endothelial growth factor (VEGF) is expressed in the facial ectoderm. Both pathways activate the MAP kinase cascade and can be suppressed by SU5402. We placed a bead soaked in SU5402 into the brain after emigration of neural crest cells was complete.
resultsWithin 24 hr we observed reduced pMEK and pERK staining that persisted for at least 48 hr. This was accompanied by significant apoptosis in the face. By day 15, the upper beaks were truncated. Molecular changes in the FNP were also apparent. Normally, Shh is expressed in the frontonasal ectodermal zone and controls patterned growth of the upper jaw. In treated embryos, Shh expression was reduced. Both the structural and molecular deficits were mitigated after transplantation of FNP-derived mesenchymal cells.
conclusionsThus, mesenchymal cells actively participate in signaling interactions of the face, and the absence of neural crest cells in neurocristopathies may not be merely structural.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.