ReviewNature reviews. Cardiology2012
Management of hypertension in the elderly.
Review in Nature reviews. Cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Hypertension in Older Persons: A Systematic Review of National and International Treatment Guidelines.Journal of clinical hypertension (Greenwich, Conn.) · 2015Pooled it
- Guideline
- Effects of Age, Sex, and Race on the Safety and Pharmacokinetics of Single and Multiple Doses of Azilsartan Medoxomil in Healthy Subjects.Clinical pharmacokinetics · 2016Trial
- Sustained effect of resistance training on blood pressure and hand grip strength following a detraining period in elderly hypertensive women: a pilot study.Clinical interventions in aging · 2014Trial
- Life stage-specific heterogeneity in the effects of adiposity transition on hypertension incidence and resolution.International journal of obesity (2005) · 2026Article
- A Nomogram for Predicting the Risk of Spinal Anesthesia-Induced Hypotension in Older Patients.Diagnostics (Basel, Switzerland) · 2026Article
- Effects of Whey Protein Supplementation on Body Composition, Muscular Strength, and Cardiometabolic Health in Older Adults: A Systematic Review with Pairwise Meta-Analysis.Healthcare (Basel, Switzerland) · 2025Review
- Associations Between Metal-Metal Interaction and the Risk of Hypertension: A Case-Control Study in Chinese Community-Dwelling Elderly.Cardiovascular toxicology · 2025Article
- Article
- Blood pressure in the longevous population with different status of hypertension and frailty.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Prevalence and determinants of resistant hypertension in the delta region of Egypt: A prospective observational study.Health science reports · 2023Article
- Pathophysiology, Diagnosis, and Management of Hypertension in the Elderly.The International journal of angiology : official publication of the International College of Angiology, Inc · 2022Article
- The association of antihypertensive use and depressive symptoms in a large older population with hypertension living in Australia and the United States: a cross-sectional study.Journal of human hypertension · 2020Article
- Prevalence and Predictors of Co-occurring Hypertension and Depression Among Community-Dwelling Older Adults.Journal of racial and ethnic health disparities · 2020Article
- DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells.Circulation · 2020Article
- Role of Thioredoxin in Age-Related Hypertension.Current hypertension reports · 2018Review
- Cardiovascular risk in rural workers and its relation with body mass index.Archives of endocrinology and metabolism · 2018Article
- Prevalence, management and control of hypertension in older adults on admission to hospital.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2017Article
- Article
- Primary prevention of cardiovascular disease in older adults in China.World journal of clinical cases · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertension is the most-prevalent modifiable risk factor for cardiovascular morbidity and mortality worldwide. Hypertension is highly prevalent among older adults (≥65 years), and aging of the population will substantially increase the prevalence of this condition. Age-related endothelial dysfunction and increased arterial stiffness contribute to the increased prevalence of hypertension, particularly systolic hypertension, among the elderly. The incidence of some forms of secondary hypertension also increases with age, mainly owing to the use of drugs (especially NSAIDs that have pressor effects) and the presence of chronic kidney disease, obstructive sleep apnea, and renal artery stenosis. Guidelines differ in thresholds and goals for antihypertensive drug therapy in the elderly because of a paucity of high-level evidence from randomized controlled trials and inconsistencies in the definition of 'elderly'. Medical treatment of hypertension reduces cardiovascular morbidity and mortality in the elderly, and all guidelines recommend lifestyle modifications and medical treatment for elderly patients whose blood pressure exceeds prescribed thresholds and who are at moderate or high cardiovascular disease risk. In the absence of comorbidities, which constitute 'compelling indications' for the use of specific antihypertensive drugs or drug classes, no clear evidence exists to support recommendations for the use of particular antihypertensive-drug classes in older adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.