Evidence map›Paper›PMID 22411171›Full record

SynthesisSleep & breathing = Schlaf & Atmung2013

Effects of continuous positive airway pressure on glycemic control and insulin resistance in patients with obstructive sleep apnea: a meta-analysis.

Dan Yang, Zhihong Liu, Haixing Yang, Qin Luo

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Sleep & breathing = Schlaf & Atmung, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 9 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 9 syntheses or guidelines pooled it, 113 citations in OpenAlex.

  1. Pooled it
  2. Sleep apnea and eye diseases: evidence of association and potential pathogenic mechanisms.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Meta-analyses of the Association of Sleep Apnea with Insulin Resistance, and the Effects of CPAP on HOMA-IR, Adiponectin, and Visceral Adipose Fat.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2015
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Trial
  11. CPAP, weight loss, or both for obstructive sleep apnea.The New England journal of medicine · 2014
    Trial
  12. Mechanisms Linking Sleep-Disordered Breathing and Cardiometabolic Disease Risk.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Personalized Medicine and Obstructive Sleep Apnea.Journal of personalized medicine · 2022
    Review
  18. Article
  19. Obstructive sleep apnea screening, diagnosis, and treatment in the transportation industry.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Dan YangState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China.
Zhihong Liu
Haixing Yang
Qin Luo
Chinese Academy of Medical Sciences & Peking Union Medical College · CNWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies addressing the question of whether continuous positive airway pressure (CPAP) could improve the insulin resistance and glucose control in patients with obstructive sleep apnea (OSA) have led to conflicting results. Therefore, we conducted the meta-analysis to evaluate the effects of CPAP on glycemic control and insulin resistance in OSA patients.

methodsWe searched PubMed, HighWire Press, Ovid Medline (R), Cochrane library, and EMBASE before December 2011 on original English language studies. The meta-analysis was conducted using Review Manager Version 5.

resultsThe summary estimate for mean difference of homeostasis model assessment insulin resistance (HOMA) from 12 non-diabetic studies was -0.55 (95 % CI, -0.91 to -0.20; P = 0.002). When compared with fasting blood glucose at baseline, 3 to 24 weeks of CPAP treatment did not improve glycemic control in non-diabetic subjects (-0.12; 95 % CI, -0.3 to 0.06; P = 0.20), as well as in diabetic subjects (-0.71; 95 % CI, -2.24 to 0.83; P = 0.37). There were no intervention-related changes in body mass index.

conclusionsOur analysis showed that CPAP significantly improved insulin resistance in non-diabetic patients with moderate to severe OSA, while no significant change in body mass index was detected. Compared with fasting blood glucose at baseline, there was no change in glycemic control with CPAP. Further large-scale, randomized, and controlled studies are needed to evaluate the longer treatment and its possible effects on weight loss and glycemic homeostasis.

Indexed as

Continuous Positive Airway PressureBlood GlucoseBody Mass IndexDiabetes Mellitus, Type 2HomeostasisHumansInsulin ResistanceReference ValuesSleep Apnea, ObstructiveBlood Glucose

Identifiers

PMID22411171
OpenAlexW2025232426

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.