ArticleThe Journal of physiology2012
Long-lasting potentiation of hippocampal synaptic transmission by direct cortical input is mediated via endocannabinoids.
Article in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Impact of Omega-3 on Endocannabinoid System Expression and Function, Enhancing Cognition and Behavior in Male Mice.Nutrients · 2024Article
- Inhibition of 2-arachidonoylglycerol degradation enhances glial immunity by single-cell transcriptomic analysis.Journal of neuroinflammation · 2023Article
- Activity-Dependent Modulation of Tonic GABA Currents by Endocannabinoids inFrontiers in synaptic neuroscience · 2022Article
- Activation of PLCβ1 enhances endocannabinoid mobilization to restore hippocampal spike-timing-dependent potentiation and contextual fear memory impaired by Alzheimer's amyloidosis.Alzheimer's research & therapy · 2021Article
- Lights on Endocannabinoid-Mediated Synaptic Potentiation.Frontiers in molecular neuroscience · 2020Review
- Diacylglycerol Lipase-Alpha Regulates Hippocampal-Dependent Learning and Memory Processes in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Dopamine-endocannabinoid interactions mediate spike-timing-dependent potentiation in the striatum.Nature communications · 2018Article
- Functional Relevance of Endocannabinoid-Dependent Synaptic Plasticity in the Central Nervous System.ACS chemical neuroscience · 2018Review
- Robustness of STDP to spike timing jitter.Scientific reports · 2018Article
- Endocannabinoid-LTP Mediated by CB1 and TRPV1 Receptors Encodes for Limited Occurrences of Coincident Activity in Neocortex.Frontiers in cellular neuroscience · 2018Article
- Synaptic functions of endocannabinoid signaling in health and disease.Neuropharmacology · 2017Review
- Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory.Neuron · 2017Article
- Hippogate: a break-in from entorhinal cortex.Nature neuroscience · 2016Article
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- Long-term Potentiation at Temporoammonic Path-CA1 Synapses in Freely Moving Rats.Frontiers in neural circuits · 2016Article
- GABA and Endocannabinoids Mediate Depotentiation of Schaffer Collateral Synapses Induced by Stimulation of Temperoammonic Inputs.PloS one · 2016Article
- The Corticohippocampal Circuit, Synaptic Plasticity, and Memory.Cold Spring Harbor perspectives in biology · 2015Review
- Article
- Endocannabinoids mediate bidirectional striatal spike-timing-dependent plasticity.The Journal of physiology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Hippocampal CA1 pyramidal neurons receive sensory inputs from the entorhinal cortex directly through the perforant path (PP) and indirectly through Schaffer collaterals (SC). Direct cortical inputs to CA1 pyramidal neurons through the PP provide instructive signals for hippocampal long-term synaptic plasticity. However, the molecules conveying synaptic signalling in this new form of heterosynaptic plasticity remain unclear. Endocannabinoids, important endogenous signalling mediators, modulate synaptic efficacy primarily through inhibition of GABAergic or glutamatergic synaptic transmission via presynaptically expressed CB1 receptors. Here, we report that pairing of direct and indirect cortical inputs to CA1 pyramidal neurons resulted in a long-lasting potentiation of synaptic responses at SC synapses, but not at the PP. The pairing-potentiated synaptic transmission at the SC was accompanied by a reduced ratio of paired-pulse facilitation (PPR). Enhanced synaptic response at the SC by pairing of PP–SC stimuli is Ca(2+) dependent and requires the presence of functional GABAergic and glutamatergic synaptic transmissions and activation of group I metabotropic glutamate receptors. Pharmacological inhibition or genetic deletion of the CB1 receptor eliminated the pairing-induced long-term synaptic plasticity and decreased PPR at the SC. The potentiation induced by pairing of PP–SC stimuli primarily is the glutamatergic synaptic transmission. While the pairing-induced long-lasting potentiation of synaptic response was blocked by inhibitors for diacylglycerol lipase (DGL), which biosynthesizes 2-AG, inhibition of monoacylglycerol lipase (MAGL), which metabolizes 2-AG, facilitated the potentiation at SC synapses by pairing of weak PP–SC stimuli. Our results suggest that 2-AG functions as a signalling mediator tuning synaptic efficacy at the proximal synapses of hippocampal CA1 pyramidal neurons while direct and indirect cortical inputs to the same neurons are spatiotemporally primed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.